New perspectives on natural products in TB drug research

被引：116
作者：
Pauli, GF
Case, RJ
Inui, T
Wang, YH
Cho, SY
Fischer, NH
Franzblau, SG
机构：
[1] Univ Illinois, Dept Med Chem & Pharmacognosy, Chicago, IL 60612 USA
[2] Univ Illinois, Inst TB Res, Chicago, IL 60612 USA
[3] Univ Mississippi, Sch Pharm, Pharmaceut Sci Res Inst, Dept Pharmacognosy, University, MS 38677 USA
[4] Univ Mississippi, Sch Pharm, Pharmaceut Sci Res Inst, Natl Ctr Nat Prod Res, University, MS 38677 USA
来源：
LIFE SCIENCES | 2005年 / 78卷 / 05期
关键词：
drug discovery; natural products; Mycobacterium tuberculosis; dormancy; bioassay-guided fractionation;
D O I：
10.1016/j.lfs.2005.09.004
中图分类号：
R-3 [医学研究方法]; R3 [基础医学];
学科分类号：
1001 ;
摘要：
The challenge of discovering new, urgently needed anti-TB drugs from natural sources requires a truly interdisciplinary research. Cutting-edge mycobacteriology and innovative natural products chemistry tools have to be developed and employed in tandem, in order to meet these demands. The present review provides cross-linkage to the most recent literature on anti-TB active natural products and summarizes the recent developments in both fields and their potential to impact the early steps of the TB drug discovery process. (c) 2005 Elsevier Inc. All rights reserved.
引用
收藏
页码：485 / 494
页数：10
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