Phenol Ugi-smiles systems:: strategies for the multicomponent N-arylation of primary amines with isocyanides, aldehydes, and phenols

被引：154

作者：

El Kaïm, L ^{[1
]}

Grimaud, L ^{[1
]}

Oble, J ^{[1
]}

机构：

[1] Ecole Natl Super Tech Avancees, CNRS, UMR 7652, Chim Organ Lab, F-75015 Paris, France

来源：

ANGEWANDTE CHEMIE-INTERNATIONAL EDITION | 2005年 / 44卷 / 48期

关键词：

amines; arylation; multicomponent reaction; phenols; rearrangement;

D O I：

10.1002/anie.200502636

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

(Chemical Equation Presented) A Smiles rearrangement is the key step in the efficient coupling of primary amines with isocyanides, carbonyl compounds, and electron-deficient substituted phenols to form N-aryl amines (see picture). The presence of a nitro or ester group on the resulting adduct allows applications in heterocyclic synthesis. © 2005 Wiley-VCH Verlag GmbH & Co. KGaA.

引用

页码：7961 / 7964

页数：4

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