Effects of gestational age at birth on health outcomes at 3 and 5 years of age: population based cohort study

被引:305
作者
Boyle, Elaine M. [1 ]
Poulsen, Gry [2 ]
Field, David J. [1 ]
Kurinczuk, Jennifer J. [2 ]
Wolke, Dieter [3 ,4 ]
Alfirevic, Zarko [5 ]
Quigley, Maria A. [2 ]
机构
[1] Univ Leicester, Dept Hlth Sci, Leicester LE1 6TP, Leics, England
[2] Univ Oxford, Natl Perinatal Epidemiol Unit, Oxford OX3 7LF, England
[3] Univ Warwick, Dept Psychol, Coventry CV4 7AL, W Midlands, England
[4] Univ Warwick, Warwick Med Sch, Div Mental Hlth & Wellbeing, Coventry CV4 7AL, W Midlands, England
[5] Univ Liverpool, Dept Womens & Childrens Hlth, Inst Translat Med, Liverpool Womens Hosp, Liverpool L8 7SS, Merseyside, England
来源
BMJ-BRITISH MEDICAL JOURNAL | 2012年 / 344卷
基金
美国国家卫生研究院;
关键词
LATE-PRETERM BIRTH; INTERNATIONAL SURVEY; INFANTS BORN; TERM INFANTS; MORBIDITY; MORTALITY; CHILDREN; ADOLESCENTS; VALIDITY; RISK;
D O I
10.1136/bmj.e896
中图分类号
R5 [内科学];
学科分类号
1002 ; 100201 ;
摘要
Objective To investigate the burden of later disease associated with moderate/late preterm (32-36 weeks) and early term (37-38 weeks) birth. Design Secondary analysis of data from the Millennium Cohort Study (MCS). Setting Longitudinal study of infants born in the United Kingdom between 2000 and 2002. Participants 18 818 infants participated in the MCS. Effects of gestational age at birth on health outcomes at 3 (n=14 273) and 5 years (n=14 056) of age were analysed. Main outcome measures Growth, hospital admissions, longstanding illness/disability, wheezing/asthma, use of prescribed drugs, and parental rating of their children's health. Results Measures of general health, hospital admissions, and longstanding illness showed a gradient of increasing risk of poorer outcome with decreasing gestation, suggesting a "dose-response" effect of prematurity. The greatest contribution to disease burden at 3 and 5 years was in children born late/moderate preterm or early term. Population attributable fractions for having at least three hospital admissions between 9 months and 5 years were 5.7% (95% confidence interval 2.0% to 10.0%) for birth at 32-36 weeks and 7.2% (1.4% to 13.6%) for birth at 37-38 weeks, compared with 3.8% (1.3% to 6.5%) for children born very preterm (<32 weeks). Similarly, 2.7% (1.1% to 4.3%), 5.4% (2.4% to 8.6%), and 5.4% (0.7% to 10.5%) of limiting longstanding illness at 5 years were attributed to very preterm birth, moderate/late preterm birth, and early term birth. Conclusions These results suggest that health outcomes of moderate/late preterm and early term babies are worse than those of full term babies. Additional research should quantify how much of the effect is due to maternal/fetal complications rather than prematurity itself.
引用
收藏
页数:14
相关论文
共 30 条
  • [11] Ketende S., 2008, Millennium cohort study third survey
  • [12] The contribution of mild and moderate preterm birth to infant mortality
    Kramer, MS
    Demissie, K
    Yang, H
    Platt, RW
    Sauvé, R
    Liston, R
    [J]. JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION, 2000, 284 (07): : 843 - 849
  • [13] Psychiatric Morbidity in Adolescents and Young Adults Born Preterm: A Swedish National Cohort Study
    Lindstrom, Karolina
    Lindblad, Frank
    Hjern, Anders
    [J]. PEDIATRICS, 2009, 123 (01) : E47 - E53
  • [14] Late Preterm Infants: Birth Outcomes and Health Care Utilization in the First Year
    Mac Bird, T.
    Bronstein, Janet M.
    Hall, Richard W.
    Lowery, Curtis L.
    Nugent, Richard
    Mays, Glen P.
    [J]. PEDIATRICS, 2010, 126 (02) : E311 - E319
  • [15] Gestational Age at Delivery and Special Educational Need: Retrospective Cohort Study of 407,503 Schoolchildren
    MacKay, Daniel F.
    Smith, Gordon C. S.
    Dobbie, Richard
    Pell, Jill P.
    [J]. PLOS MEDICINE, 2010, 7 (06)
  • [16] Neonatal mortality and morbidity rates in late preterm births compared with births at term
    McIntire, Donald D.
    Leveno, Kenneth J.
    [J]. OBSTETRICS AND GYNECOLOGY, 2008, 111 (01) : 35 - 41
  • [17] Persistence of Morbidity and Cost Differences Between Late-Preterm and Term Infants During the First Year of Life
    McLaurin, Kimmie K.
    Hall, Caroline B.
    Jackson, E. Anne
    Owens, Oksana V.
    Mahadevia, Parthiv J.
    [J]. PEDIATRICS, 2009, 123 (02) : 653 - 659
  • [18] Moser K, 2007, HLTH STAT Q, V13, P27
  • [19] A simple method of determining confidence intervals for population attributable risk from complex surveys
    Natarajan, Sundar
    Lipsitz, Stuart R.
    Rimm, Eric
    [J]. STATISTICS IN MEDICINE, 2007, 26 (17) : 3229 - 3239
  • [20] Early discharge and readmission to hospital in the first month of life in the Northern Region of the UK during 1998: a case cohort study
    Oddie, SJ
    Hammal, D
    Richmond, S
    Parker, L
    [J]. ARCHIVES OF DISEASE IN CHILDHOOD, 2005, 90 (02) : 119 - 124