A novel Fe3+ fluorescent probe based on rhodamine derivatives and its application in biological imaging

被引：12
作者：
Wang, Xing [1 ]
Huang, Jie [1 ]
Wei, Haiyan [1 ]
Wu, Linyun [1 ]
Xing, Haizhu [2 ]
Zhu, Jing [2 ]
Kan, Chun [1 ]
机构：
[1] Nanjing Forestry Univ, Coll Sci, Dept Chem & Mat Sci, 159 LongpanRd, Nanjing 210037, Peoples R China
[2] Nanjing Univ Chinese Med, Dept Pharm, Jiangsu Key Lab Pharmacol & Safety Evaluat Chinese, 138 XianlinDadao, Nanjing 210023, Peoples R China
来源：
JOURNAL OF MOLECULAR STRUCTURE | 2022年 / 1270卷
关键词：
Fluorescence sensing; Fe3+; Quick check; Biological imagine; SENSOR; CHEMOSENSOR; IONS; SELECTIVITY; HG2+;
D O I：
10.1016/j.molstruc.2022.133979
中图分类号：
O64 [物理化学（理论化学）、化学物理学];
学科分类号：
070304 ; 081704 ;
摘要：
In this paper, rhodamine B was used as the fluorophore to design and synthesize a probe RBPH for Fe3+ detection. The properties of the probe RBPH were investigated by UV-Vis absorption spectroscopy and fluorescence emission spectroscopy. The results showed that the probe had a detection limit of 75.9 nM and a binding constant of 0.608 x 10(4) M-1. Compared with the published rhodamine B class Fe3+ probes, the probe RBPH has the advantage of rapid response. Biological experiments show that the probe has good biocompatibility, low toxicity and good cell penetration ability. The probe RBPH can be successfully applied to the determination of Fe3+ ions in Hela cells and zebrafish, and a good fluorescence imaging effect can be seen by laser confocal microscopy. (c) 2022 Elsevier B.V. All rights reserved.
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页数：7
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