Genetic variants in the tumor necrosis factor receptor 1 gene in patients with MS

被引：19

作者：

Weinshenker, BG

Hebrink, D

Wingerchuk, DM

Klein, CJ

Atkinson, E

O'Brien, PC

McMurray, CT

机构：

[1] Mayo Clin & Mayo Fdn, Dept Neurol, Rochester, MN 55902 USA

[2] Mayo Clin, Dept Hlth Sci Res, Rochester, MN USA

[3] Mayo Clin, Dept Pharmacol, Rochester, MN USA

来源：

NEUROLOGY | 1999年 / 52卷 / 07期

关键词：

D O I：

10.1212/WNL.52.7.1500

中图分类号：

R74 [神经病学与精神病学];

学科分类号：

摘要：

We scanned for all genetic Variants in functionally important regions of the tumor necrosis factor receptor 1 gene (TNF-R1) in 100 to 111 MS patients from Olmsted County, MN, and analyzed selected variants for an association with disease course and severity. Ten genetic variants were uncovered. Only one variant, a silent substitution, was found in coding sequence. One intronic variant may generate a novel splice-junction sequence. We did not find an association between either this intronic variant or another common promoter variant and the course or severity of MS.

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页码：1500 / 1503

页数：4

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