Approaches to chemical synthetic biology

被引：6

作者：

Chiarabelli, Cristiano ^{[1
]}

Stano, Pasquale ^{[1
]}

Anella, Fabrizio ^{[1
]}

Carrara, Paolo ^{[1
]}

Luisi, Pier Luigi ^{[1
]}

机构：

[1] Univ Roma Tre, Dept Biol, I-00146 Rome, Italy

来源：

FEBS LETTERS | 2012年 / 586卷 / 15期

关键词：

Minimal Cell; Lipid vesicle; Random sequence; RNA stability; Protein folding; DE-NOVO; PROTEIN-SYNTHESIS; GENE-EXPRESSION; FOLDED PROTEINS; SEQUENCE SPACE; MINIMAL CELLS; RNA MOTIFS; IN-VITRO; STABILITY; LIPOSOMES;

D O I：

10.1016/j.febslet.2012.01.014

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Synthetic biology is first represented in terms of two complementary aspects, the bio-engineering one, based on the genetic manipulation of extant microbial forms in order to obtain forms of life which do not exist in nature; and the chemical synthetic biology, an approach mostly based on chemical manipulation for the laboratory synthesis of biological structures that do not exist in nature. The paper is mostly devoted to shortly review chemical synthetic biology projects currently carried out in our laboratory. In particular, we describe: the minimal cell project, then the "Never Born Proteins" and lastly the Never Born RNAs. We describe and critically analyze the main results, emphasizing the possible relevance of chemical synthetic biology for the progress in basic science and biotechnology. (C) 2012 Federation of European Biochemical Societies. Published by Elsevier B. V. All rights reserved.

引用

页码：2138 / 2145

页数：8

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