Impact of the C1431T Polymorphism of the Peroxisome Proliferator Activated Receptor-Gamma (PPAR-γ) Gene on Fasted Serum Lipid Levels in Patients with Coronary Artery Disease

被引：35
作者：
Oladi, Mohammadreza [1 ]
Nohtani, Mahdi [2 ,3 ]
Avan, Amir [3 ,4 ]
Mirhafez, Seyed Reza [5 ]
Tajbakhsh, Amir [3 ,6 ]
Ghasemi, Faezeh [3 ]
Asadi, Asadollah [2 ]
Salmani, Mahmoud Elahdadi [7 ]
Mohammadi, Akram [3 ]
Hoseinzadeh, Leila [3 ]
Ferns, Gordon A. [8 ]
Mobarhan, Majid Ghayour [3 ,4 ]
机构：
[1] Mashhad Univ Med Sci, Pharmaceut Res Ctr, Mashhad, Iran
[2] Mohaghegh Ardebili Univ, Fac Sci, Dept Biol, Ardebil, Iran
[3] Mashhad Univ Med Sci, Sch Med, Dept Modern Sci & Technol, Mashhad, Iran
[4] Mashhad Univ Med Sci, Sch Med, Biochem Nutr Res Ctr, Mashhad, Iran
[5] Neyshabur Univ Med Sci, Dept Basic Med Sci, Neyshabur, Iran
[6] Mashhad Univ Med Sci, Cardiovasc Res Ctr, Sch Med, Mashhad, Iran
[7] Damghan Univ, Fac Sci, Dept Biol, Damghan, Iran
[8] Brighton & Sussex Med Sch, Div Med Educ, Brighton, E Sussex, England
来源：
ANNALS OF NUTRITION AND METABOLISM | 2015年 / 66卷 / 2-3期
关键词：
PPAR-gamma C1431T polymorphism; Coronary artery disease; Lipid profile; C161T POLYMORPHISM; METABOLIC SYNDROME; HEART-DISEASE; ALPHA GENE; ASSOCIATION; PRO12ALA; VARIANTS; RISK; SUSCEPTIBILITY; HAPLOTYPES;
D O I：
10.1159/000381358
中图分类号：
R5 [内科学];
学科分类号：
1002 ; 100201 ;
摘要：
Background/Aims: The C1431T polymorphism of peroxisome proliferator activated receptor-gamma (PPAR-gamma) gene is related to diabetes and metabolic-syndrome. However, studies have been inconclusive about its association with coronary artery disease (CAD) and there have been no studies analyzing the association of this polymorphism with fasted-serum-lipid levels in Iranian-individuals with CAD. We investigated the association of PPAR-gamma C1431T-polymorphism with CAD and dyslipidaemia in 787 individuals. Methods: Anthropometric-parameters and biochemical-measurements were evaluated, followed by genotyping. The association of the genetic-polymorphisms with CAD and lipid-profile was determined by univariate/multivariate-analyses. Results: Patients with CT or CT+ TT genotype were at an increased-risk of CAD relative to CC-carriers (adjusted odds ratio: 2.03; 95% confidence interval, 1.01-4.09; p = 0.046). However, in the larger population, CT genotype was present at a higher frequency in the group with a positive angiogram. Furthermore, CT+ TT genotypes were associated with an altered fasted-lipid-profile in the initial population sample of patients with a positive angiogram, compared to the group with a negative-angiogram. The angiogram-positive patients carrying the T allele had a significantly higher triglyceride, serum C-reactive protein and fasting-blood-glucose. Conclusion: We have found the PPAR-gamma C1431T polymorphism was significantly associated with fasted serum lipid profile in individuals with angiographically defined CAD. Since accumulating data support the role of PPAR-gamma polymorphisms in CAD, further studies are required to investigate the association of this polymorphism with coronary artery disease. (C) 2015 S. Karger AG, Basel
引用
收藏
页码：149 / 154
页数：6
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