A two-scale model for simultaneous sintering and crystallization of glass-ceramic scaffolds for tissue engineering

被引：21

作者：

Huang, R. ^{[1
]}

Pan, J. ^{[1
]}

Boccaccini, A. R. ^{[2
]}

Chen, Q. Z. ^{[2
]}

机构：

[1] Univ Leicester, Dept Engn, Leicester LE1 7RH, Leics, England

[2] Univ London Imperial Coll Sci Technol & Med, Dept Mat, London SW7 2BP, England

来源：

ACTA BIOMATERIALIA | 2008年 / 4卷 / 04期

基金：

英国工程与自然科学研究理事会;

关键词：

bioactive glass; sintering; crystallization; model;

D O I：

10.1016/j.actbio.2008.02.004

中图分类号：

R318 [生物医学工程];

学科分类号：

0831 ;

摘要：

Bioglass (R)-based glass-ceramic foams have been developed recently as highly porous, mechanically competent, bioactive and degradable scaffolds for bone tissue engineering. However, the development of the material so far has been based on a trial-and-error approach, and the existing materials are far from being optimized. In this paper, a mechanism-based model is presented for sintering deformation of Bioglass (R) foams. The porous foams consist of struts which, in turn, consist of Bioglass (R) particles. A corresponding two-scale model is developed based on existing viscous sintering models. Crystallization plays a key role in the sintering deformation of Bioglass (R) foams and is taken into account in the model. Qualitative comparison between the model predictions and experimental observations is presented, showing that the model is able to capture the complicated interplay between crystallization and viscous flow during the sintering process. (C) 2008 Acta Materialia Inc. Published by Elsevier Ltd. All rights reserved.

引用

页码：1095 / 1103

页数：9

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