Wound repair: a showcase for cell plasticity and migration

被引：175

作者：

Shaw, Tanya J. ^{[1
]}

Martin, Paul ^{[2
,3
,4
,5
]}

机构：

[1] Kings Coll London, Ctr Mol & Cellular Biol Inflammat, London SE1 1UL, England

[2] Univ Bristol, Sch Biochem, Bristol BS8 1TD, Avon, England

[3] Univ Bristol, Sch Physiol & Pharmacol, Bristol BS8 1TD, Avon, England

[4] Cardiff Univ, Sch Med, Cardiff CF14 4XN, S Glam, Wales

[5] Nanyang Technologicial Univ, Lee Kong Chiang Sch Med, Singapore, Singapore

来源：

CURRENT OPINION IN CELL BIOLOGY | 2016年 / 42卷

基金：

英国医学研究理事会; 英国生物技术与生命科学研究理事会; 英国惠康基金;

关键词：

MESENCHYMAL STEM-CELLS; SMOOTH MUSCLE ACTIN; INTEGRIN EXPRESSION; HEALING RESPONSE; TISSUE-REPAIR; SKIN; KERATINOCYTES; ALPHA; INFLAMMATION; ACTIVATION;

D O I：

10.1016/j.ceb.2016.04.001

中图分类号：

Q2 [细胞生物学];

学科分类号：

071009 ; 090102 ;

摘要：

A skin wound requires several cell lineages to exhibit considerable plasticity as they migrate towards and over the site of damage to contribute to repair. The keratinocytes that re-epithelialize the tissue, the dermal fibroblasts and potentially other mesenchymal stem cell populations that repopulate damaged connective tissue, the immune cells that counter infections, and endothelial cells that re-establish blood supply and facilitate the immune response - all of these cells are 'dynamic' in that they are activated by immediate wound cues, they reprogram to adopt cell behaviours essential for repair including migration, and finally they must resolve. In adult tissues, repair is unique in its requirement for dramatic cell changes and movements otherwise associated only with development and disease.

引用

页码：29 / 37

页数：9

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