Single-molecule insights into mRNA dynamics in neurons

被引：60

作者：

Buxbaum, Adina R. ^{[1
,2
,3
]}

Yoon, Young J. ^{[1
]}

Singer, Robert H. ^{[1
,2
,3
]}

Park, Hye Yoon ^{[3
,4
,5
]}

机构：

[1] Albert Einstein Coll Med, Dept Anat & Struct Biol, Bronx, NY 10461 USA

[2] Albert Einstein Coll Med, Gruss Lipper Biophoton Ctr, Bronx, NY 10461 USA

[3] Howard Hughes Med Inst, Ashburn, VA 20147 USA

[4] Seoul Natl Univ, Dept Phys & Astron, Seoul 151747, South Korea

[5] Seoul Natl Univ, Inst Mol Biol & Genet, Seoul 151742, South Korea

来源：

TRENDS IN CELL BIOLOGY | 2015年 / 25卷 / 08期

基金：

美国国家卫生研究院;

关键词：

RNA localization; mRNA tracking; local translation; smFISH; LOCAL PROTEIN-SYNTHESIS; MENTAL-RETARDATION PROTEIN; KAPPA-OPIOID-RECEPTOR; SYNAPTIC PLASTICITY; HIPPOCAMPAL-NEURONS; DENDRITIC SPINES; SELECTIVE LOCALIZATION; TRANSLATIONAL CONTROL; NMDA RECEPTOR; RAT-BRAIN;

D O I：

10.1016/j.tcb.2015.05.005

中图分类号：

Q2 [细胞生物学];

学科分类号：

071009 ; 090102 ;

摘要：

Targeting of mRNAs to neuronal dendrites and axons plays an integral role in intracellular signaling, development, and synaptic plasticity. Single-molecule imaging of mRNAs in neurons and brain tissue has led to enhanced understanding of mRNA dynamics. Here we discuss aspects of mRNA regulation as revealed by single-molecule detection, which has led to quantitative analyses of mRNA diversity, localization, transport, and translation. These exciting new discoveries propel our understanding of the life of an mRNA in a neuron and how its activity is regulated at the single-molecule level.

引用

页码：468 / 475

页数：8

共 56 条

[1] Dynamic visualization of local protein synthesis in hippocampal neurons [J].

Aakalu, G ;

Smith, WB ;

Nguyen, N ;

Jiang, CG ;

Schuman, EM .

NEURON, 2001, 30 (02) :489-502

[2] Distinct role of long 3′ UTR BDNF mRNA in spine morphology and synaptic plasticity in hippocampal neurons [J].

An, Juan Ji ;

Gharami, Kusumika ;

Liao, Guey-Ying ;

Woo, Newton H. ;

Lau, Anthony G. ;

Vanevski, Filip ;

Torre, Enrique R. ;

Jones, Kevin R. ;

Feng, Yue ;

Lu, Bai ;

Xu, Baoji .

CELL, 2008, 134 (01) :175-187

[3] Neuronal mRNAs travel singly into dendrites [J].

Batish, Mona ;

van den Bogaard, Patrick ;

Kramer, Fred Russell ;

Tyagi, Sanjay .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 2012, 109 (12) :4645-4650

[4]

Berry FB, 1996, J NEUROSCI RES, V43, P565, DOI 10.1002/(SICI)1097-4547(19960301)43:5<565::AID-JNR6>3.0.CO

[5]

2-G

[6] Copb1-facilitated axonal transport and translation of κ opioid-receptor mRNA [J].

Bi, Jing ;

Tsai, Nien-Pei ;

Lu, Hsin-Yi ;

Loh, Horace H. ;

Wei, Li-Na .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 2007, 104 (34) :13810-13815

[7] Axonal mRNA transport and localized translational regulation of κ-opioid receptor in primary neurons of dorsal root ganglia [J].

Bi, Jing ;

Tsai, Nien-Pei ;

Lin, Ya-Ping ;

Loh, Horace H. ;

Wei, Li-Na .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 2006, 103 (52) :19919-19924

[8] Translational Control in Synaptic Plasticity and Cognitive Dysfunction [J].

Buffington, Shelly A. ;

Huang, Wei ;

Costa-Mattioli, Mauro .

ANNUAL REVIEW OF NEUROSCIENCE, VOL 37, 2014, 37 :17-38

[9]

BURGIN KE, 1990, J NEUROSCI, V10, P1788

[10] In the right place at the right time: visualizing and understanding mRNA localization [J].

Buxbaum, Adina R. ;

Haimovich, Gal ;

Singer, Robert H. .

NATURE REVIEWS MOLECULAR CELL BIOLOGY, 2015, 16 (02) :95-109

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