Bone Health During the Menopause Transition and Beyond

被引：124

作者：

Karlamangla, Arun S. ^{[1
]}

Burnett-Bowie, Sherri-Ann M. ^{[2
]}

Crandall, Carolyn J. ^{[3
]}

机构：

[1] Univ Calif Los Angeles, David Geffen Sch Med, Div Geriatr, 10945 Le Conte Ave 2339, Los Angeles, CA 90095 USA

[2] Harvard Med Sch, Massachusetts Gen Hosp, Endocrinol Div, 55 Fruit St, Boston, MA 02114 USA

[3] Univ Calif Los Angeles, David Geffen Sch Med, Div Gen Internal Med & Hlth Serv Res, 911 Broxton Ave,1st Floor, Los Angeles, CA 90024 USA

来源：

OBSTETRICS AND GYNECOLOGY CLINICS OF NORTH AMERICA | 2018年 / 45卷 / 04期

基金：

美国国家卫生研究院;

关键词：

Perimenopause; Bone strength; Bone turnover markers; Transmenopausal bone loss; Race/ethnicity differences; Bone loss trajectories; Osteoporosis; Fracture; FEMORAL-NECK STRENGTH; FRACTURE RISK-ASSESSMENT; FINAL MENSTRUAL PERIOD; ADULT WOMEN FINDINGS; TASK-FORCE STRATEGY; MINERAL DENSITY; HIP FRACTURE; VASOMOTOR SYMPTOMS; BODY-SIZE; VITAMIN-D;

D O I：

10.1016/j.ogc.2018.07.012

中图分类号：

R71 [妇产科学];

学科分类号：

100211 ;

摘要：

The menopause transition is a critical period for bone health, with rapid losses in bone mass and strength occurring in a 3-year window bracketing the date of the final menstrual period. Declines in bone mass are accompanied by deleterious changes in bone macrostructure and microarchitecture, which may be captured by changes in composite strength indices and indices of trabecular thickness and connectivity. The onset of the rapid bone loss phase is preceded by changes in sex steroid hormones and increases in markers of bone resorption, measurements of which may be clinically useful in predicting the onset of the rapid loss phase and in identifying the women who will lose the most bone strength over the menopause transition.

引用

页码：695 / +

页数：15

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