Mesoporous silica nanoparticles in biomedical applications

被引：1627

作者：

Li, Zongxi ^{[1
,2
]}

Barnes, Jonathan C. ^{[3
,4
,5
]}

Bosoy, Aleksandr ^{[3
,4
,5
]}

Stoddart, J. Fraser ^{[3
,4
,5
]}

Zink, Jeffrey I. ^{[1
,2
]}

机构：

[1] Univ Calif Los Angeles, Calif NanoSyst Inst, Los Angeles, CA 90095 USA

[2] Univ Calif Los Angeles, Dept Chem & Biochem, Los Angeles, CA 90095 USA

[3] Northwestern Univ, Dept Chem, Evanston, IL 60208 USA

[4] Korea Adv Inst Sci & Technol, NanoCentury KAIST Inst, Taejon 305701, South Korea

[5] Korea Adv Inst Sci & Technol, Grad Sch EEWS WCU, Taejon 305701, South Korea

来源：

CHEMICAL SOCIETY REVIEWS | 2012年 / 41卷 / 07期

关键词：

DRUG-DELIVERY RATE; CANCER-CELLS; ORGANIC MODIFICATION; CONTROLLED-RELEASE; SURFACE-CHARGE; MCM-41; DOXORUBICIN; NANOCARRIERS; TUMOR; SIZE;

D O I：

10.1039/c1cs15246g

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

This tutorial review provides an outlook on nanomaterials that are currently being used for theranostic purposes, with a special focus on mesoporous silica nanoparticle (MSNP) based materials. MSNPs with large surface area and pore volume can serve as efficient carriers for various therapeutic agents. The functionalization of MSNPs with molecular, supramolecular or polymer moieties, provides the material with great versatility while performing drug delivery tasks, which makes the delivery process highly controllable. This emerging area at the interface of chemistry and the life sciences offers a broad palette of opportunities for researchers with interests ranging from sol-gel science, the fabrication of nanomaterials, supramolecular chemistry, controllable drug delivery and targeted theranostics in biology and medicine.

引用

页码：2590 / 2605

页数：16

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