Synthesis of enantiomerically pure 3-aminochroman derivatives

被引：12
|
作者：
Usse, S
Pave, G
Guillaumet, G
Viaud-Massuard, MC
机构：
[1] Univ Orleans, UMR CNRS 6005, Inst Chim Organ & Anal, F-45067 Orleans 2, France
[2] UFR Sci Pharmaceut, Chim Organ Lab, F-37200 Tours, France
来源：
TETRAHEDRON-ASYMMETRY | 2001年 / 12卷 / 12期
关键词：
D O I：
10.1016/S0957-4166(01)00202-6
中图分类号：
O61 [无机化学];
学科分类号：
070301 ; 081704 ;
摘要：
Enantiomerically pure (3R)-amino-5-methoxy-3,4-dihydro-2H-1-benzopyran was successfully synthesised in nine steps starting from L-serine. The same synthetic pathway was used to prepare the (3 S) -aminochroman derivative starting from D-serine. The enantiomeric purity of the final aminochroman derivatives was determined by capillary electrophoresis using P-cyclodextrin as the chiral selector. (C) 2001 Elsevier Science Ltd. All rights reserved.
引用
收藏
页码：1689 / 1694
页数：6
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