A Role for MAIT Cells in Colorectal Cancer

被引：15

作者：

Berzins, Stuart P. ^{[1
,2
,3
]}

Wallace, Morgan E. ^{[1
,2
]}

Kannourakis, George ^{[1
,2
]}

Kelly, Jason ^{[1
,2
]}

机构：

[1] Fiona Elsey Canc Res Inst, Ballarat, Vic, Australia

[2] Federat Univ Australia, Mt Helen, Vic, Australia

[3] Univ Melbourne, Peter Doherty Inst Infect & Immun, Dept Microbiol & Immunol, Melbourne, Vic, Australia

来源：

FRONTIERS IN IMMUNOLOGY | 2020年 / 11卷

关键词：

MAIT cells; colorectal cancer; IL-13; tumor immunity; human immunity; INVARIANT T-CELLS; TISSUE-REPAIR; INFLAMMATION; ACTIVATION; TCR; CARCINOMA; TARGETS; SUBSET; TUMORS; TREG;

D O I：

10.3389/fimmu.2020.00949

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

MAIT cells are MR1-restricted T cells that are well-known for their anti-microbial properties, but they have recently been associated with different forms of cancer. Several studies have reported activated MAIT cells within the microenvironment of colorectal tumors, but there is conjecture about the nature of their response and whether they are contributing to anti-tumor immunity, or to the progression of the disease. We have reviewed the current state of knowledge about the role of MAIT cells in colorectal cancer, including their likely influence when activated and potential sources of stimulation in the tumor microenvironment. The prospects for MAIT cells being used in clinical settings as biomarkers or as targets of new immunotherapies designed to harness their function are discussed.

引用

页数：7

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