Increasing trend of type 1 diabetes incidence in the pediatric population of the Calabria region in 2019-2021

被引：18

作者：

Passanisi, Stefano ^{[1
]}

Salzano, Giuseppina ^{[1
]}

Aloe, Monica ^{[2
]}

Bombaci, Bruno ^{[1
]}

Citriniti, Felice ^{[3
]}

De Berardinis, Fiorella ^{[4
]}

De Marco, Rosaria ^{[5
]}

Lazzaro, Nicola ^{[6
]}

Lia, Maria C. ^{[7
]}

Lia, Rosanna ^{[8
]}

Mammi, Francesco ^{[8
]}

Stamati, Filomena A. ^{[9
]}

Toscano, Rosanna M. R. ^{[10
]}

Ventrici, Claudia ^{[11
]}

Iafusco, Dario ^{[12
]}

Lombardo, Fortunato ^{[1
]}

机构：

[1] Univ Messina, Dept Human Pathol Adult & Dev Age Gaetano Barresi, Via Consolare Valeria 1, I-98124 Messina, ME, Italy

[2] Osped Civile Giovanni Paolo II, SOC Pediat, Lamezia Terme, Italy

[3] Azienda Osped Pugliese, UOC Pediat, Catanzaro, Italy

[4] Osped Spoke G Iannelli, SOC Pediat, Cetraro, Italy

[5] Azienda Osped Cosenza, UOC Pediat, Cosenza, Italy

[6] Osped San Giovanni Dio, SOC Pediat, Crotone, Italy

[7] Azienda Osped BMM, UOC Pediat, Reggio Di Calabria, Italy

[8] Osped Civile Locri, SOC Pediat & Neonatol, Locri, Italy

[9] Osped Civile Ferrari, SOC Pediat & Neonatol, Castrovillari, Italy

[10] Osped Civile Iazzolino, SOC Pediat & Neonatol, Vibo Valentia, Italy

[11] Osped Civile Santa Maria Ungheresi, SOC Pediat & Neonatol, Polistena, Italy

[12] Univ Campania Luigi Vanvitelli, Dept Woman Child & Gen & Specialized Surg, Naples, Italy

来源：

ITALIAN JOURNAL OF PEDIATRICS | 2022年 / 48卷 / 01期

关键词：

Children; Diabetic ketoacidosis; Epidemiology; SARS-CoV-2; CHILDREN; PREVALENCE; MANAGEMENT; AGE;

D O I：

10.1186/s13052-022-01264-z

中图分类号：

R72 [儿科学];

学科分类号：

100202 ;

摘要：

Background Although type 1 diabetes (T1D) represents one of the most common chronic diseases in pediatric age, few studies on the epidemiology of T1D exist globally and the exact prevalence and incidence rates of the disease are unknown. In many countries, including Italy, national registries are missing. Methods This study aims to assess T1D incidence in the pediatric population of the Calabria region (southern Italy) in the period 2019-2021. The secondary objective was to describe the main demographical, clinical and immunological features of incident cases. Case ascertainment and all clinical data were assessed by retrospectively reviewing the electronic medical records of children and adolescents diagnosed with diabetes at any Pediatric Diabetes Center belonging to the Rete Diabetologica Calabrese (Calabria Region Diabetes Network), from January 2019 to December 2021. The incidence of T1D was estimated for the entire region and was stratified according to age group (0-4 years, 5-9 years, and 10-14 years) and gender. Standardized incidence ratios for each province in the region were also calculated. Results The crude incidence of T1D was 20.6/100,000 person/years. Incidence rates were higher among females and children aged 5-9 years. The crude incidence of T1D was higher in the province of Reggio Calabria (26.5/100,000 person-years). The provinces of Crotone, Catanzaro, and Vibo Valentia showed significantly lower standardized incidence ratios. The annual incidence in the region progressively increased by 43% during the study period. Conclusions Our study revealed a relatively high incidence in the Calabria region. The marked increasing incidence trend over the past two years could be related to the global impact of the COVID-19 pandemic, but further long-scale population-based studies are needed to confirm these findings.

引用

页数：8

共 39 条

[1] Global and regional estimates of the morbidity due to type I diabetes among children aged 0-4 years: a systematic review and analysis [J].