Immunoglobulin G subclasses in antibody responses to St. Louis encephalitis virus infections

被引:7
作者
Ivana Spinsanti, Lorena [1 ]
Alejandro Farias, Adrian [1 ]
Javier Aguilar, Juan [1 ]
del Pilar Diaz, Maria [2 ]
Silvia Contigiani, Marta [1 ]
机构
[1] Univ Nacl Cordoba, Fac Ciencias Med, Inst Virol Dr JM Vanella, RA-5016 Cordoba, Argentina
[2] Univ Nacl Cordoba, Escuela Nutr, Fac Ciencias Med, RA-5016 Cordoba, Argentina
关键词
St. Louis encephalitis virus; IgG isotypes; Immune response; LINKED-IMMUNOSORBENT-ASSAY; IMMUNE-COMPLEXES; IGG SUBCLASSES; DENGUE VIRUS; HUMAN SERA; ARGENTINA; OUTBREAK; SEROPREVALENCE; PROTEIN;
D O I
10.1007/s00705-011-1047-3
中图分类号
Q93 [微生物学];
学科分类号
071005 ; 100705 ;
摘要
The aim of this study was to recognize the specific antiviral response patterns of IgG1, IgG2, IgG3 and IgG4 subclasses, elicited during St. Louis encephalitis virus (SLEV) infection in humans. Eighty-five samples of human sera from 44 patients with SLEV infection were obtained between days 1 and 365 or later, after onset of the disease. These samples were processed by immunofluorescence assay for detection of IgG1-, IgG2-, IgG3- and IgG4-specific antibodies. We demonstrate the presence of all isotypes of IgG for more than a year in patients infected with SLEV. However; isotype IgG1 was present at the highest titers, with a peak between days 8 and 30 after onset of the disease.
引用
收藏
页码:1861 / 1864
页数:4
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