Endothelin-1 in plasma, cisternal CSF and microdialysate following aneurysmal SAH

被引：42
作者：
Kästner, S [1 ]
Oertel, MF [1 ]
Scharbrodt, W [1 ]
Krause, M [1 ]
Böker, DK [1 ]
Deinsberger, W [1 ]
机构：
[1] Univ Hosp Giessen, Dept Neurosurg, Giessen, Germany
来源：
ACTA NEUROCHIRURGICA | 2005年 / 147卷 / 12期
关键词：
microdialysis; vasospasm; endothelin; subarachnoid haemorrhage;
D O I：
10.1007/s00701-005-0633-0
中图分类号：
R74 [神经病学与精神病学];
学科分类号：
摘要：
Objective. Endothelin-1 (ET-1) is postulated to play an important role in the development of cerebral vasospasm (CVS) following SAH. This study was conducted to investigate the time course of ET-release in three different sources: CSF, plasma and microdialysate. Methods. In a prospective study ET-1-concentrations were measured in plasma, cisternal CSF and microdialysate in 20 patients with aneurysmal SAH for at least 8 days after hemorrhage. Results. ET-1 concentration in microdialysate was almost four times higher compared to CSF and plasma. (p < 0.001) Only in CSF ET-1-release showed a significant increase over time with highest values on day 5 post ictus (p = 0.03). This was parallel to the increase of transcranial Doppler velocities. ET-1 in plasma and microdialysate did not change over time. Conclusion. ET-1 may have a different biological function in different biological tissues. Only ET-1 in CSF seemed to be associated with CVS.
引用
收藏
页码：1271 / 1279
页数：9
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