The diverse and complex roles of NF-κB subunits in cancer

被引：752

作者：

Perkins, Neil D. ^{[1
]}

机构：

[1] Newcastle Univ, Sch Med, Inst Cell & Mol Biosci, Newcastle Upon Tyne NE2 4HH, Tyne & Wear, England

来源：

NATURE REVIEWS CANCER | 2012年 / 12卷 / 02期

基金：

英国惠康基金;

关键词：

PUTATIVE TUMOR-SUPPRESSOR; TARGET GENE-EXPRESSION; POSTTRANSLATIONAL MODIFICATIONS; DEPENDENT TRANSCRIPTION; NEGATIVE REGULATOR; DOWN-REGULATION; MICE LACKING; CELL-GROWTH; MOUSE MODEL; CROSS-TALK;

D O I：

10.1038/nrc3204

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

It is only recently that the full importance of nuclear factor-kappa B (NF-kappa B) signalling to cancer development has been understood. Although much attention has focused on the upstream pathways leading to NF-kappa B activation, it is now becoming clear that the inhibitor of NF-kappa B kinases (IKKs), which regulate NF-kappa B activation, have many independent functions in tissue homeostasis and normal immune function that could compromise the clinical utility of IKK inhibitors. Therefore, if the NF-kappa B pathway is to be properly exploited as a target for both anticancer and anti-inflammatory drugs, it is appropriate to reconsider the complex roles of the individual NF-kappa B subunits.

引用

页码：121 / 132

页数：12

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