Chiral tertiary alcohols made by catalytic enantioselective addition of unreactive zinc reagents to poorly electrophilic ketones?

被引：181
作者：
Ramón, DJ [1 ]
Yus, M [1 ]
机构：
[1] Univ Alicante, Fac Ciencias, Dept Quim Organ, Alicante 03080, Spain
来源：
ANGEWANDTE CHEMIE-INTERNATIONAL EDITION | 2004年 / 43卷 / 03期
关键词：
alcohols; asymmetric catalysis; C-C coupling; enantioselectivity; zinc;
D O I：
10.1002/anie.200301696
中图分类号：
O6 [化学];
学科分类号：
0703 ;
摘要：
Ligands that activate both the starting ketone and the zinc reagent are essential in catalyzing enantioselective nucleophilic additions yielding tertiary alcohols [Eq. (1)]. Controlled generation of compounds with such quaternary stereogenic centers is one of the major challenges in synthetic organic chemistry.
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页码：284 / 287
页数：4
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