Biosynthesis of silver nanoparticles using dried fruit extract of Ficus carica - Screening for its anticancer activity and toxicity in animal models

被引:51
|
作者
Jacob, S. Justin Packia [1 ]
Prasad, V. L. Siva [1 ]
Sivasankar, S. [1 ]
Muralidharan, P. [2 ]
机构
[1] St Josephs Coll Engn, Dept Biotechnol, Madras 600119, Tamil Nadu, India
[2] CL Baid Metha Coll Pharm, Dept Pharmacol, Madras 600119, Tamil Nadu, India
关键词
Ficus carica; Nanoparticle; Cytotoxicity; MCF7cells; Acute toxicity; HEP-2; CELL-LINE; CYTOTOXIC ACTIVITY;
D O I
10.1016/j.fct.2017.03.066
中图分类号
TS2 [食品工业];
学科分类号
0832 ;
摘要
There is an increasing commercial demand for various nanoparticles due to their extensive applicability in various areas such as electronics, catalysis, chemistry, energy and medicine. Metallic nanoparticles are traditionally synthesized by wet chemical techniques, where the chemicals used are quite often toxic and flammable. Fig has been a typical fruit component of the health-promoting Mediterranean diet for a very long time. In the present study, we describe a cost effective and eco-friendly technique for green synthesis of silver nanoparticles from 1 mM AgNO3 solution through the extract of dried fig (Ficus carica L) fruit as reducing as well as capping agent. Nanoparticles were characterized using UV absorption spectroscopy and SEM. The sizes of the spherical silver particles were found to be in the range of 54 -89 nm. The biologically synthesized nanoparticles also exhibited a significant cytotoxic effect on MCF7cell lines and further animal acute toxicity results state that the above AgNPs are toxicologically safe by oral administration. (C) 2017 Elsevier Ltd. All rights reserved.
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页码:951 / 956
页数:6
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