Delivery of repurposed disulfiram by aminated mesoporous silica nanoparticles for anticancer therapy

被引：9

作者：

Aquib, Md ^{[1
]}

Zhang, Hang ^{[2
]}

Raza, Faisal ^{[1
,3
]}

Banerjee, Parikshit ^{[1
,4
]}

Bavi, Rohit ^{[2
,5
]}

Kesse, Samuel ^{[1
,3
]}

Boakye-Yiadom, Kofi Oti ^{[1
,3
]}

Filli, Mensura Sied ^{[1
]}

Farooq, Muhammad Asim ^{[1
]}

Wang, Bo ^{[1
]}

机构：

[1] China Pharmaceut Univ, Sch Pharm, Dept Pharmaceut, Nanjing 211198, Jiangsu, Peoples R China

[2] China Pharmaceut Univ, Sch Engn, Dept Biomed Engn, State Key Lab Nat Med, 24 Tongjia Xiang, Nanjing 210009, Gulou District, Peoples R China

[3] Shanghai Jiao Tong Univ, Sch Pharm, Shanghai 200240, Peoples R China

[4] Chinese Univ Hong Kong, Fac Med, Sch Pharm, Shatin, Hong Kong, Peoples R China

[5] Punyashlok Ahilyadevi Holkar Solapur Univ, Sch Chem Sci, Solapur 413255, Maharashtra, India

来源：

JOURNAL OF MOLECULAR LIQUIDS | 2022年 / 346卷

关键词：

Cancer; Repurposed drug; Disulfiram; Aminated mesoporous silica nanoparticles; Drug delivery; KAPPA-B ACTIVITY; DRUG-DELIVERY; IN-VITRO; HEMOLYTIC-ACTIVITY; CONTROLLED-RELEASE; OXIDATIVE STRESS; CANCER-THERAPY; CELL-DEATH; SIZE; IMPROVEMENT;

D O I：

10.1016/j.molliq.2021.117065

中图分类号：

O64 [物理化学（理论化学）、化学物理学];

学科分类号：

070304 ; 081704 ;

摘要：

Herein, aminated mesoporous silica nanoparticles (AMPSNPs) were developed by using the cocondensation process and were further explored as a nanocarrier for disulfiram (DSF) delivery, which is classified as a "repurposed drug" for a variety of cancer therapies. The optimized DSF loading and encapsulation efficiency were found to be 18.05 +/- 0.62% and 93.01 +/- 0.83%, respectively. The scanning electron microscopy (SEM) showed a spherical and uniform formation of optimized AMPSNPs. Transmission electron microscopy (TEM) clearly displayed that the developed silica nanoparticles (NPs) contain mesostructures in them. For discovering a successful formation of an anticancer drug delivery system, various physicochemical characterization techniques were studied, such as PXRD, DSC, and FTIR. Hemolysis study revealed a better blood compatibility of the synthesized AMPSNPs. Furthermore, in vitro cellular cytotoxicity assay displayed an excellent cytotoxic profile of DSF-AMPSMPs compared to that of free DSF. Additionally, in vivo anti-tumor study conducted on A549 tumor-bearing nude mice verified a substantial tumor volume suppression and greater tumor growth inhibition with DSF-AMPSNP treatment group compared to using blank-AMPSNP and the free DSF group, with limited adverse-effects on mice health. Thus, we fervently have confidence that the AMPSNP could be utilized as a capable drug carrier for the delivery of DSF in cancer therapies.

引用

页数：13

共 94 条

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