Novel SNPs of the mtDNA ND5 gene and their associations with several growth traits in the Nanyang cattle breed

被引：14
|
作者：
Zhang, Bao [1 ]
Chen, Hong [1 ,2 ]
Hua, Liushuai [1 ]
Zhang, Chunlei [1 ]
Kang, Xiangtao [1 ]
Wang, Xinzhuang [3 ]
Pan, Chuanying [1 ]
Lan, Xianyong [1 ]
Lei, Chuzhao [1 ]
机构：
[1] NW A&F Univ, Shaanxi Key Lab Mol Biol Agr, Coll Anim Sci & Technol, Yangling 712100, Shaanxi, Peoples R China
[2] Xuzhou Normal Univ, Inst Cellular & Mol Biol, Jiangsu 221116, Peoples R China
[3] Res Ctr Cattle Engn Technol Henan, Zhengzhou 450003, Henan, Peoples R China
来源：
BIOCHEMICAL GENETICS | 2008年 / 46卷 / 5-6期
基金：
中国国家自然科学基金;
关键词：
cattle; mtDNA; ND5; gene polymorphism; single nucleotide polymorphism (SNP); growth traits;
D O I：
10.1007/s10528-008-9152-z
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
Polymorphism of the mtDNA ND5 gene was detected by PCR-SSCP and DNA sequencing methods in 714 individuals from six Chinese cattle breeds. The results showed that at the P2 locus, two kinds of haplotypes, named A and B, with three SNPs (T12900C, A12923T, C12924T) were detected. The frequencies of haplotype A in six breeds were 0.041-0.167. Polymorphism of the ND5 gene was shown to be associated with growth in the Nanyang breed. Individuals with haplotype B had greater hucklebone width than those with haplotype A when 6 months old (P < 0.01), as well as better body height, body length, body weight, and average daily gain at 6 months (P < 0.05). Therefore, haplotype B of the ND5 gene was likely to have a positive effect on growth traits at 6 months in the Nanyang breed.
引用
收藏
页码：362 / 368
页数：7
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