Salt loading with unilateral nephrectomy accelerates decline in glomerular filtration rate in the hypertensive, obese, type 2 diabetic SDT fatty rat model of diabetic kidney disease

被引：2

作者：

Shinozaki, Yuichi ^{[1
]}

Katayama, Yuko ^{[2
]}

Yamaguchi, Fuminari ^{[2
]}

Suzuki, Tomohisa ^{[2
]}

Watanabe, Kana ^{[3
]}

Uno, Kinuko ^{[3
]}

Tsutsui, Takahiro ^{[1
]}

Sugimoto, Miki ^{[1
]}

Shinohara, Masami ^{[4
]}

Miyajima, Katsuhiro ^{[3
]}

Ohta, Takeshi ^{[1
]}

机构：

[1] Kyoto Univ, Grad Sch Agr, Lab Anim Physiol & Funct Anat, Kyoto 6068502, Japan

[2] SCOHIA PHARMA Inc, Res Div, Kanagawa, Japan

[3] Tokyo Univ Agr, Fac Appl Biosci, Dept Nutr Sci & Food Safety, Tokyo, Japan

[4] CLEA Japan Inc, Tokyo, Japan

来源：

CLINICAL AND EXPERIMENTAL PHARMACOLOGY AND PHYSIOLOGY | 2022年 / 49卷 / 04期

关键词：

GFR decline; salt loading; SDT fatty rat; unilateral nephrectomy; RENAL-DISEASE; NEPHROPATHY; HYPERGLYCEMIA; BLOCKADE; HYPOXIA; STRESS;

D O I：

10.1111/1440-1681.13621

中图分类号：

R9 [药学];

学科分类号：

1007 ;

摘要：

For the evaluation of novel therapeutic agents for diabetic kidney disease (DKD), it is desirable to examine their efficacy in animal models by using the glomerular filtration rate (GFR) as an index. For this purpose, animal models that demonstrate a short-term GFR decline because of disease progression are required. Therefore, we aimed to develop such an animal model of DKD by using obese type 2 diabetic spontaneously diabetic Torii (SDT) fatty rats treated with salt loading by drinking water containing sodium chloride with or without unilateral nephrectomy. As a result, we have found that 0.3% salt loading with unilateral nephrectomy or 0.8% salt loading alone caused a rapid GFR decline, hypertension and rapid development of tubulointerstitial fibrosis. Moreover, the addition of losartan to a mixed diet suppressed the GFR decline in SDT fatty rats treated with 0.3% salt loading with unilateral nephrectomy. These results suggest that the model of SDT fatty rats treated with 0.3% salt loading and unilateral nephrectomy could be used as a hypertensive DKD model for evaluating therapeutic agents based on suppression of GFR decline.

引用

页码：492 / 500

页数：9

共 21 条

[21] Prevalence of diabetic nephropathy among Chinese patients with type 2 diabetes mellitus and different categories of their estimated glomerular filtration rate based on the Chronic Kidney Disease Epidemiology Collaboration (CKD-EPI) equation in primary care in Hong Kong: a cross-sectional study
Mok, Ka Yee
Chan, Pang Fai
Lai, Loretta K. P.
Chow, Kai Lim
Chao, David V. K.
JOURNAL OF DIABETES AND METABOLIC DISORDERS, 2019, 18 (02) : 281 - 288

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