Isolation and Detection of Proteins with Nano-Particles and Microchips for Analyzing Proteomes on a Large Scale Basis

被引：5

作者：

Chan, Ki ^{[1
,2
]}

Tzi Bun Ng ^{[2
]}

机构：

[1] Univ Hong Kong, Fac Dent, Biomed & Tissue Engn Res Grp, Prince Philip Dent Hosp, Hong Kong, Hong Kong, Peoples R China

[2] Chinese Univ Hong Kong, Fac Med, Sch Biomed Sci, Shatin, Hong Kong, Peoples R China

来源：

PROTEIN AND PEPTIDE LETTERS | 2011年 / 18卷 / 04期

关键词：

Nanoparticles; micro-total-analysis systems; lab-on-a-chip; capillary electrochromatography; LIQUID-CRYSTALLINE NANOPARTICLES; ELECTROPHORETIC SEPARATIONS; MASS-SPECTROMETRY; AMINO-ACIDS; ELECTROCHROMATOGRAPHY; LECTIN; CHROMATOGRAPHY; PEPTIDES; DESIGN; PHASES;

D O I：

10.2174/092986611794653978

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

The advent of sugar-immobilized gold nano-particles (SGNPs), lipid-based nanoparticles, nano-chromatography and nano-electrophoresis has revolutionized the methodology for proteins purification and proteomic research. This review provides an overview on the effective method developed for fast purification of proteins from extracts using SGNPs. In addition, the current application of microfluidic systems for analytical purposes in biochemistry will also be explored that include the micro total analysis systems (mu-TAS) and lab-on-a-chip (LOC) analyses which are capable of isolation and detection of proteins at the nanogram level. Finally, we describe why the lipid-based nano-particles (LBNPs) can enable the analysis in microchip electroseparation and how anionic and cationic LBNPs can be used for proteins separation.

引用

页码：423 / 433

页数：11

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