Mannose-binding lectin serum levels in patients with leprosy are influenced by age and MBL2 genotypes

被引：17

作者：

Silva Vasconcelos, Luydson Richardson ^{[1
,2
]}

Lopes Fonseca, Juliana Pereira ^{[1
]}

do Carmo, Rodrigo Feliciano ^{[1
]}

de Mendonca, Taciana Furtado ^{[1
]}

Alves Pereira, Valeria Rego ^{[3
]}

Lucena-Silva, Norma ^{[3
,4
]}

Moreira Beltrao Pereira, Leila Maria ^{[1
,2
]}

Moura, Patricia ^{[1
]}

de Mendonca Cavalcanti, Maria do Socorro ^{[1
]}

机构：

[1] Univ Fed Pernambuco, Inst Ciencias Biol, Fac Ciencias Med, BR-50100130 Recife, PE, Brazil

[2] Intituto Figado Pernambuco, BR-50100130 Recife, PE, Brazil

[3] Fiocruz MS, Ctr Pesquisas Aggeu Magalhaes, BR-50670420 Recife, PE, Brazil

[4] Inst Med Integral Prof Fernando Figueira, BR-50070550 Recife, PE, Brazil

来源：

INTERNATIONAL JOURNAL OF INFECTIOUS DISEASES | 2011年 / 15卷 / 08期

关键词：

Mannose-binding lectin; MBL2; Leprosy; Innate immunity; Age; Polymorphism; CLINICAL LEPROSY; SUSCEPTIBILITY; GENE; POLYMORPHISMS; DEFICIENCY; PROTEIN; ASSOCIATION; POPULATIONS; PREVALENCE; INSIGHTS;

D O I：

10.1016/j.ijid.2011.04.008

中图分类号：

R51 [传染病];

学科分类号：

100401 ;

摘要：

Background: Mannose-binding lectin (MBL) activates the complement system promoting opsonophagocytosis, which could represent an advantage for Mycobacterium leprae, an intracellular pathogen. Therefore, a single nucleotide polymorphism (SNP) in the MBL2 gene associated with low levels of MBL could confer protection against the development of leprosy disease. Methods: In this study, we investigated SNPs of the MBL2 gene and MBL levels in 228 Brazilian leprosy patients and 232 controls. Results: There were no differences in the frequencies of variant genotypes and haplotypes of MBL2 between patients and controls, or between the different clinical forms of leprosy. In the group of patients with a genotype for high expression of MBL2, those aged > 40 years had decreased MBL levels compared to patients aged <= 40 years (p = 0.037). Conclusion: Our results demonstrate that age could influence the phenotype of MBL2, but no evidence was found for an association of MBL2 polymorphism with susceptibility to leprosy or its clinical forms. (C) 2011 International Society for Infectious Diseases. Published by Elsevier Ltd. All rights reserved.

引用

页码：E551 / E557

页数：7

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