Pulmonary hypertension in heart failure with preserved ejection fraction: a plea for proper phenotyping and further research

被引：106

作者：

Hoeper, Marius M. ^{[1
,2
]}

Lam, Carolyn S. P. ^{[3
,4
]}

Vachiery, Jean-Luc ^{[5
]}

Bauersachs, Johann ^{[6
]}

Gerges, Christian ^{[7
]}

Lang, Irene M. ^{[7
]}

Bonderman, Diana ^{[7
]}

Olsson, Karen M. ^{[1
,2
]}

Gibbs, J. Simon R. ^{[8
,9
]}

Dorfmuller, Peter ^{[10
,11
]}

Guazzi, Marco ^{[12
]}

Galie, Nazzareno ^{[13
]}

Manes, Alessandra ^{[13
]}

Handoko, M. Louis ^{[14
]}

Vonk-Noordegraaf, Anton ^{[15
]}

Lankeit, Mareike ^{[16
]}

Konstantinides, Stavros ^{[17
,18
]}

Wachter, Rolf ^{[19
,20
]}

Opitz, Christian ^{[21
]}

Rosenkranz, Stephan ^{[22
,23
]}

机构：

[1] Hannover Med Sch, Dept Resp Med, Carl Neuberg Str 1, D-30625 Hannover, Germany

[2] Hannover Med Sch, German Ctr Lung Res DZL, Carl Neuberg Str 1, D-30625 Hannover, Germany

[3] Natl Ctr Singapore, 5 Hosp Dr, Singapore 16960, Singapore

[4] Duke Natl Univ Singapore, 5 Hosp Dr, Singapore 16960, Singapore

[5] CUB Hop Erasme, Pulm Vasc Dis & Heart Failure Clin, Route Lennik 808, B-1070 Brussels, Belgium

[6] Hannover Med Sch, Dept Cardiol & Angiol, Carl Neuberg Str 1, D-30625 Hannover, Germany

[7] Med Univ Vienna, Div Cardiol, Dept Internal Med 2, Spitalgasse 23, A-1090 Vienna, Austria

[8] Imperial Coll, Natl Heart & Lung Inst, Sydney St, London SW3 6NP, England

[9] Hammersmith Hosp, Natl Pulm Hypertens Serv, Du Cane Rd, London W12 0HS, England

[10] Paris South Univ, Marie Lannelongue Hosp, Dept Pathol, 15 Rue Georges Clemenceau, F-91400 Orsay, France

[11] Paris South Univ, Marie Lannelongue Hosp, INSERM, UMR S 999, 15 Rue Georges Clemenceau, F-91400 Orsay, France

[12] Univ Milan, IRCCS Policlin San Donato, Dept Cardiol, Piazza Edmondo Malan 1, I-20097 Milan, Italy

[13] Bologna Univ Hosp, Dept Expt Diagnost & Special Med, Via Zamboni 33, I-40126 Bologna, Italy

[14] Vrije Univ Amsterdam Med Ctr, Dept Cardiol, De Boelelaan 1117, NL-1081 Amsterdam, Netherlands

[15] Vrije Univ Amsterdam Med Ctr, Dept Pneumol, De Boelelaan 1117, NL-1081 Amsterdam, Netherlands

[16] Charite, Campus Virchow Klinikum, Dept Cardiol, Augustenburger Pl 1, D-13353 Berlin, Germany

[17] Univ Med Ctr Mainz, Ctr Thrombosis & Haemostasis, Langenbeckstr 1, D-55131 Mainz, Germany

[18] Democritus Univ Thrace, Dept Cardiol, Univ Campus, Komotini 69100, Alexandroupolis, Greece

[19] Univ Gottingen, Dept Cardiol, Robert Koch Str 40, D-37099 Gottingen, Germany

[20] German Cardiovasc Res Ctr DZHK, Robert Koch Str 40, D-37099 Gottingen, Germany

[21] DRK Kliniken Berlin, Dept Cardiol, Spandauer Damm 130, D-14050 Berlin, Germany

[22] Univ Cologne, Dept Cardiol, Kerpener Str 62, D-50937 Cologne, Germany

[23] Univ Cologne, CCRC, Kerpener Str 62, D-50937 Cologne, Germany

来源：

EUROPEAN HEART JOURNAL | 2017年 / 38卷 / 38期

关键词：

RIGHT-VENTRICULAR FUNCTION; EXERCISE HEMODYNAMICS; PRESSURE-GRADIENT; ARTERIAL CAPACITANCE; DIFFICULT DIAGNOSIS; VASCULAR-DISEASE; DYSFUNCTION; GUIDELINES; PREDICTOR; MORTALITY;

D O I：

10.1093/eurheartj/ehw597

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

Heart failure (HF) with preserved ejection fraction (HFpEF) is a common disease affecting the elderly in particular. Up to 80% of these patients develop pulmonary hypertension (PH), which is associated with worse symptoms and increased mortality.1 It is a matter of concern that drugs approved for pulmonary arterial hypertension (PAH) are sometimes used in such patients despite insufficient data for their safety and efficacy. On the other hand, the impact of PH and right ventricular (RV) dysfunction on morbidity and mortality in HFpEF call for proper attention both at the clinical and scientific level. Here we discuss the clinical problem, pathophysiology, diagnostic shortfalls, gaps in evidence, and future strategies for PH-HFpEF. © The Author 2016.

引用

页码：2869 / 2873

页数：5

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