Effects of IL-22 on cardiovascular diseases

被引：17
作者：
Che, Yang [1 ,2 ]
Su, Zhaoliang [2 ,3 ]
Xia, Lin [1 ,2 ]
机构：
[1] Jiangsu Univ, Dept Lab Med, Affiliated Hosp, 438 Jiefang Rd, Zhenjiang 212001, Jiangsu, Peoples R China
[2] Jiangsu Univ, Int Genome Ctr, Zhenjiang 212013, Jiangsu, Peoples R China
[3] Jiangsu Univ, Dept Immunol, Zhenjiang 212013, Jiangsu, Peoples R China
来源：
INTERNATIONAL IMMUNOPHARMACOLOGY | 2020年 / 81卷
基金：
中国博士后科学基金; 中国国家自然科学基金;
关键词：
IL-22; Cardiovascular diseases; Th22; cells; receptor; II CYTOKINE RECEPTOR; INTERLEUKIN; 22; IL-10; FAMILY; T-CELL; BLOOD-PRESSURE; HEART-FAILURE; MYOCARDITIS; EXPRESSION; DIFFERENTIATION; CLONING;
D O I：
10.1016/j.intimp.2020.106277
中图分类号：
R392 [医学免疫学]; Q939.91 [免疫学];
学科分类号：
100102 ;
摘要：
Interleukin-22 (IL-22), which belongs to the IL-10 family, is an alpha helix cytokine specifically produced by many lymphocytes, such as Th1, Th17, Th22, ILCs, CD4 + and CD8 + T cells. In recent years, more and more studies have demonstrated that IL-22 has an interesting relationship with various cardiovascular diseases, including myocarditis, myocardial infarction, atherosclerosis, and other cardiovascular diseases, and IL-22 signal may play a dual role in cardiovascular diseases. Here, we summarize the recent progress on the source, function, regulation of IL-22 and the effects of IL-22 signal in cardiovascular diseases. The study of IL-22 will suggest more specific strategies to maneuver these functions for the effective treatment of cardiovascular diseases and future clinical treatment.
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页数：7
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