Otx Genes in Neurogenesis of Mesencephalic Dopaminergic Neurons

被引：15

作者：

Simeone, Antonio ^{[1
,2
]}

Puelles, Eduardo ^{[3
,4
]}

Omodei, Daniela ^{[1
]}

Acampora, Dario ^{[1
,2
]}

Di Giovannantonio, Luca Giovanni ^{[1
]}

Di Salvio, Michela ^{[1
]}

Mancuso, Pietro ^{[1
]}

Tomasetti, Carmine ^{[1
]}

机构：

[1] SEMM European Sch Mol Med, CEINGE Biotecnol Avanzate, I-80145 Naples, Italy

[2] CNR, Inst Genet & Biophys A Buzzati Traverso, I-80131 Naples, Italy

[3] CSIC, Inst Neurociencias Alicante, Sant Joan dAlacant 03550, Spain

[4] Univ Miguel Hernandez, Sant Joan dAlacant 03550, Spain

来源：

DEVELOPMENTAL NEUROBIOLOGY | 2011年 / 71卷 / 08期

关键词：

mesencephalic dopaminergic differentiation; Otx; Fgf8; Shh; Wnt1; VENTRAL TEGMENTAL AREA; CYCLIN D1; BETA-CATENIN; TRANSCRIPTIONAL REPRESSION; ANTERIOR NEUROECTODERM; DEVELOPMENT REQUIRES; NEURAL PLATE; CELL FATE; MIDBRAIN; EXPRESSION;

D O I：

10.1002/dneu.20877

中图分类号：

Q [生物科学];

学科分类号：

07 ; 0710 ; 09 ;

摘要：

Mesencephalic-diencephalic dopaminergic (mdDA) neurons play a relevant role in the control of movement, behavior, and cognition. Indeed loss and/or abnormal functioning of mdDA neurons are responsible for Parkinson's disease as well as for addictive and psychiatric disorders. In the last years a wealth of information has been provided on gene functions controlling identity, fate, and proliferation of mdDA progenitors. This review will focus on the role exerted by Otx genes in early decisions regulating sequential steps required for the neurogenesis of mesencephalic dopaminergic (mesDA) neurons. In this context, the regulatory network involving Otx functional interactions with signaling molecules and transcription factors required to promote or prevent the development of mesDA neurons will be analyzed in detail. (C) 2011 Wiley Periodicals, Inc. Develop Neurobiol 71: 665-679, 2011

引用

页码：665 / 679

页数：15

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