Otx Genes in Neurogenesis of Mesencephalic Dopaminergic Neurons

被引：14
作者：
Simeone, Antonio [1 ,2 ]
Puelles, Eduardo [3 ,4 ]
Omodei, Daniela [1 ]
Acampora, Dario [1 ,2 ]
Di Giovannantonio, Luca Giovanni [1 ]
Di Salvio, Michela [1 ]
Mancuso, Pietro [1 ]
Tomasetti, Carmine [1 ]
机构：
[1] SEMM European Sch Mol Med, CEINGE Biotecnol Avanzate, I-80145 Naples, Italy
[2] CNR, Inst Genet & Biophys A Buzzati Traverso, I-80131 Naples, Italy
[3] CSIC, Inst Neurociencias Alicante, Sant Joan dAlacant 03550, Spain
[4] Univ Miguel Hernandez, Sant Joan dAlacant 03550, Spain
来源：
DEVELOPMENTAL NEUROBIOLOGY | 2011年 / 71卷 / 08期
关键词：
mesencephalic dopaminergic differentiation; Otx; Fgf8; Shh; Wnt1; VENTRAL TEGMENTAL AREA; CYCLIN D1; BETA-CATENIN; TRANSCRIPTIONAL REPRESSION; ANTERIOR NEUROECTODERM; DEVELOPMENT REQUIRES; NEURAL PLATE; CELL FATE; MIDBRAIN; EXPRESSION;
D O I：
10.1002/dneu.20877
中图分类号：
Q [生物科学];
学科分类号：
07 ; 0710 ; 09 ;
摘要：
Mesencephalic-diencephalic dopaminergic (mdDA) neurons play a relevant role in the control of movement, behavior, and cognition. Indeed loss and/or abnormal functioning of mdDA neurons are responsible for Parkinson's disease as well as for addictive and psychiatric disorders. In the last years a wealth of information has been provided on gene functions controlling identity, fate, and proliferation of mdDA progenitors. This review will focus on the role exerted by Otx genes in early decisions regulating sequential steps required for the neurogenesis of mesencephalic dopaminergic (mesDA) neurons. In this context, the regulatory network involving Otx functional interactions with signaling molecules and transcription factors required to promote or prevent the development of mesDA neurons will be analyzed in detail. (C) 2011 Wiley Periodicals, Inc. Develop Neurobiol 71: 665-679, 2011
引用
收藏
页码：665 / 679
页数：15
相关论文
共 88 条
  • [1] Acampora D, 1998, DEVELOPMENT, V125, P5091
  • [2] Acampora D, 1997, DEVELOPMENT, V124, P3639
  • [3] Selective inactivation of Otx2 mRNA isoforms reveals isoform-specific requirement for visceral endoderm anteriorization and head morphogenesis and highlights cell diversity in the visceral endoderm
    Acampora, Dario
    Di Giovannantonio, Luca Giovanni
    Di Salvio, Michela
    Mancuso, Pietro
    Simeone, Antonio
    [J]. MECHANISMS OF DEVELOPMENT, 2009, 126 (10) : 882 - 897
  • [4] Sonic hedgehog control of size and shape in midbrain pattern formation
    Agarwala, S
    Sanders, TA
    Ragsdale, CW
    [J]. SCIENCE, 2001, 291 (5511) : 2147 - 2150
  • [5] Meis2 competes with the Groucho co-repressor Tle4 for binding to Otx2 and specifies tectal fate without induction of a secondary midbrain-hindbrain boundary organizer
    Agoston, Zsuzsa
    Schulte, Dorothea
    [J]. DEVELOPMENT, 2009, 136 (19): : 3311 - 3322
  • [6] Andersson E, 2006, CELL, V124, P393, DOI [10.1016/j.cell.2005.10.037, 10.1016/J.CELL.2005.10.037]
  • [7] Development of the mesencephalic dopaminergic neuron system is compromised in the absence of neurogenin 2
    Andersson, E
    Jensen, JB
    Parmar, M
    Guillemot, F
    Björklund, A
    [J]. DEVELOPMENT, 2006, 133 (03): : 507 - 516
  • [8] Wnt5a Regulates Ventral Midbrain Morphogenesis and the Development of A9-A10 Dopaminergic Cells In Vivo
    Andersson, Emma R.
    Prakash, Nilima
    Cajanek, Lukas
    Minina, Eleonora
    Bryja, Vitezslav
    Bryjova, Lenka
    Yamaguchi, Terry P.
    Hall, Anita C.
    Wurst, Wolfgang
    Arenas, Ernest
    [J]. PLOS ONE, 2008, 3 (10):
  • [9] Arber N, 1997, CANCER RES, V57, P1569
  • [10] Bjorklund A., 1984, HDB CHEM NEUROANATOM, V2, P55
123456789