Trend in blood lead levels in Taiwanese adults 2005-2017

被引：4

作者：

Fang, Chun-Wan ^{[1
,2
]}

Ning, Hsiao-Chen ^{[2
,3
]}

Huang, Ya-Ching ^{[1
,2
]}

Chiang, Yu-Shao ^{[4
]}

Chuang, Chun-Wei ^{[1
]}

Wang, I-Kuan ^{[5
,6
]}

Fan, Nai-Chia ^{[7
,8
]}

Weng, Cheng-Hao ^{[8
,9
]}

Huang, Wen-Hung ^{[8
,9
]}

Hsu, Ching-Wei ^{[8
,9
]}

Yen, Tzung-Hai ^{[8
,9
]}

机构：

[1] Chang Gung Mem Hosp, Dept Lab Med, Taoyuan, Linkou, Taiwan

[2] Chang Gung Univ, Coll Med, Dept Med Biotechnol & Lab Sci, Taoyuan, Taiwan

[3] Chang Gung Mem Hosp, Dept Med Res & Dev, Taoyuan, Linkou, Taiwan

[4] Chang Gung Mem Hosp, Dept Lab Med, Kaohsiung, Taiwan

[5] China Med Univ Hosp, Dept Nephrol, Taichung, Taiwan

[6] China Med Univ, Coll Med, Taichung, Taiwan

[7] Chang Gung Mem Hosp, Dept Pediat, Div Pediat Gen Med, Linkou, Taiwan

[8] Chang Gung Univ, Coll Med, Taoyuan, Taiwan

[9] Chang Gung Mem Hosp, Clin Poison Ctr, Kidney Res Ctr, Ctr Tissue Engn,Dept Nephrol, Linkou, Taiwan

来源：

PLOS ONE | 2021年 / 16卷 / 12期

关键词：

PROGRESSIVE DIABETIC-NEPHROPATHY; GENERAL-POPULATION; CHELATION-THERAPY; UNITED-STATES; EXPOSURE; ASSOCIATION; ABSORPTION;

D O I：

10.1371/journal.pone.0260744

中图分类号：

O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];

学科分类号：

07 ; 0710 ; 09 ;

摘要：

This study examined the trend of blood lead levels (BLLs) in Taiwanese adults and analyzed the variations in the BLL between Linkou (northern) and Kaohsiung (southern) hospital branches. Between 2005 and 2017, 3,804 adult participants received blood lead tests at the Linkou (n = 2,674) and Kaohsiung (n = 1,130) branches of Chang Gung Memorial Hospital. The geometric mean of BLL was 2.77 mu g/dL. The adult participants from the Kaohsiung branch were not only age older (49.8 +/- 14.1 versus 39.4 +/- 14.2 years; P < 0.001) and male predominant (65.8 versus 41.7%; P < 0.001) but also showed a higher BLL (4.45 +/- 3.93 versus 2.82 +/- 2.42 mu g/dL; P < 0.001) and lower estimated glomerular filtration rate (87.62 +/- 25.94 versus 93.67 +/- 23.88; P < 0.001) than those from the Linkou branch. Multivariable logistic regression analysis revealed that the Kaohsiung branch [odds ratio (OR): 7.143; 95% confident interval (CI): 5.682-8.929; P < 0.001], older age (OR: 1.008; 95% CI: 1.000-1.015; P = 0.043) and reduced estimated glomerular filtration rate (OR: 1.009; 95% CI: 1.004-1.014; P = 0.001) were significant predictors for BLL > 5 mu g/dL. Therefore, this study confirmed a continuous decreasing trend in the BLL in Taiwan after banning leaded petrol in 2000.

引用

页数：12