Recent Advances of Natural and Synthetic β-Carbolines as Anticancer Agents

被引：52

作者：

Zhang, Mingming ^{[1
]}

Sun, Dianqing ^{[1
]}

机构：

[1] Univ Hawaii, Dept Pharmaceut Sci, Daniel K Inouye Coll Pharm, Hilo, HI 96720 USA

来源：

ANTI-CANCER AGENTS IN MEDICINAL CHEMISTRY | 2015年 / 15卷 / 05期

关键词：

Alkaloid; Anticancer; Antitumor; beta-Carboline; Mechanism of action; Natural product; Structure-activity relationship; POTENTIAL ANTITUMOR AGENTS; DNA INTERCALATING AGENTS; BIOLOGICAL EVALUATION; KINASE INHIBITORS; IN-VITRO; GALIANTHE-THALICTROIDES; CYTOTOXIC ACTIVITIES; HARMINE DERIVATIVES; PROTEIN-KINASE; CANCER-CELLS;

D O I：

10.2174/1871520614666141128121812

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

Cancer is a leading cause of mortality worldwide, being responsible for millions of deaths annually. Therefore, novel cancer chemotherapeutic agents are urgently needed to combat this devastating disease. beta-Carboline alkaloids are an important class of natural products and medicinal molecules, which exert their anticancer activities through diverse mechanisms. In this review, we cover recent natural and synthetic beta-carbolines with anticancer activity that have been reported in the literature (2010-July 2014), focusing on their chemical structures, anticancer properties, structure-activity relationships, and mechanisms of action.

引用

页码：537 / 547

页数：11

共 81 条

[31] A Series of Beta-Carboline Derivatives Inhibit the Kinase Activity of PLKs [J].

Han, Xiaomin ;

Zhang, Jing ;

Guo, Liang ;

Cao, Rihui ;

Li, Yongzhen ;

Li, Ni ;

Ma, Qin ;

Wu, Jialin ;

Wang, Yanchang ;

Si, Shuyi .

PLOS ONE, 2012, 7 (10)

[32] Ruthenium-Arene--Carboline Complexes as Potent Inhibitors of Cyclin-Dependent Kinase1: Synthesis, Characterization and Anticancer Mechanism Studies [J].

He, Liang ;

Liao, Si-Yan ;

Tan, Cai-Ping ;

Ye, Rui-Rong ;

Xu, Yu-Wen ;

Zhao, Meng ;

Ji, Liang-Nian ;

Mao, Zong-Wan .

CHEMISTRY-A EUROPEAN JOURNAL, 2013, 19 (36) :12152-12160

[33] Hainanerectamines A-C, Alkaloids from the Hainan Sponge Hyrtios erecta [J].

He, Wen-Fei ;

Xue, Duo-Qing ;

Yao, Li-Gong ;

Li, Jing-Ya ;

Li, Jia ;

Guo, Yue-Wei .

MARINE DRUGS, 2014, 12 (07) :3982-3993

[34] HR22C16: A potent small-molecule probe for the dynamics of cell division [J].

Hotha, S ;

Yarrow, JC ;

Yang, JG ;

Garrett, S ;

Renduchintala, KV ;

Mayer, TU ;

Kapoor, TM .

ANGEWANDTE CHEMIE-INTERNATIONAL EDITION, 2003, 42 (21) :2379-2382

[35] Antimalarial β-Carboline and Indolactam Alkaloids from Marinactinospora thermotolerans, a Deep Sea Isolate [J].

Huang, Hongbo ;

Yao, Yueliang ;

He, Zhengxiang ;

Yang, Tingting ;

Ma, Junying ;

Tian, Xinpeng ;

Li, Yayong ;

Huang, Caiguo ;

Chen, Xiaoping ;

Li, Wenjun ;

Zhang, Si ;

Zhang, Changsheng ;

Ju, Jianhua .

JOURNAL OF NATURAL PRODUCTS, 2011, 74 (10) :2122-2127

[36] 7,8-Dichloro-1-oxo-β-carbolines as a Versatile Scaffold for the Development of Potent and Selective Kinase Inhibitors with Unusual Binding Modes [J].

Huber, Kilian ;

Brault, Laurent ;

Fedorov, Oleg ;

Gasser, Christelle ;

Filippakopoulos, Panagis ;

Bullock, Alex N. ;

Fabbro, Doriano ;

Trappe, Joerg ;

Schwaller, Juerg ;

Knapp, Stefan ;

Bracher, Franz .

JOURNAL OF MEDICINAL CHEMISTRY, 2012, 55 (01) :403-413

[37] Structure-activity relationship in the antitumor activity of 6-, 8- or 6,8-substituted 3-benzylamino-β-carboline derivatives [J].

Ikeda, Reiko ;

Kimura, Takanori ;

Tsutsumi, Tatsuya ;

Tamura, Syunsuke ;

Sakai, Norio ;

Konakahara, Takeo .

BIOORGANIC & MEDICINAL CHEMISTRY LETTERS, 2012, 22 (10) :3506-3515

[38] 3-(3-Phenoxybenzyl)amino-β-carboline: A novel antitumor drug targeting α-tubulin [J].

Ikeda, Reiko ;

Kurosawa, Masaki ;

Okabayashi, Takazumi ;

Takei, Ayako ;

Yoshiwara, Masamichi ;

Kumakura, Tadashi ;

Sakai, Norio ;

Funatsu, Osamu ;

Morita, Akinori ;

Ikekita, Masahiko ;

Nakaike, Yumi ;

Konakahara, Takeo .

BIOORGANIC & MEDICINAL CHEMISTRY LETTERS, 2011, 21 (16) :4784-4787

[39] 3-Benzylamino-β-carboline derivatives induce apoptosis through G2/M arrest in human carcinoma cells He La S-3 [J].

Ikeda, Reiko ;

Iwaki, Toshie ;

Iida, Tomoko ;

Okabayashi, Takasumi ;

Nishi, Eishiro ;

Kurosawa, Masaki ;

Sakai, Norio ;

Konakahara, Takeo .

EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY, 2011, 46 (02) :636-646

[40] A β-Carboline Alkaloid from the Papua New Guinea Marine Sponge Hyrtios reticulatus [J].

Inman, Wayne D. ;

Bray, Walter M. ;

Gassner, Nadine C. ;

Lokey, R. Scott ;

Tenney, Karen ;

Shen, Young Yongchun ;

TenDyke, Karen ;

Suh, Ted ;

Crews, Phillip .

JOURNAL OF NATURAL PRODUCTS, 2010, 73 (02) :255-257

← 1 2 3 4 5 6 7 8 9 →