Recent Advances of Natural and Synthetic β-Carbolines as Anticancer Agents

被引：52

作者：

Zhang, Mingming ^{[1
]}

Sun, Dianqing ^{[1
]}

机构：

[1] Univ Hawaii, Dept Pharmaceut Sci, Daniel K Inouye Coll Pharm, Hilo, HI 96720 USA

来源：

ANTI-CANCER AGENTS IN MEDICINAL CHEMISTRY | 2015年 / 15卷 / 05期

关键词：

Alkaloid; Anticancer; Antitumor; beta-Carboline; Mechanism of action; Natural product; Structure-activity relationship; POTENTIAL ANTITUMOR AGENTS; DNA INTERCALATING AGENTS; BIOLOGICAL EVALUATION; KINASE INHIBITORS; IN-VITRO; GALIANTHE-THALICTROIDES; CYTOTOXIC ACTIVITIES; HARMINE DERIVATIVES; PROTEIN-KINASE; CANCER-CELLS;

D O I：

10.2174/1871520614666141128121812

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

Cancer is a leading cause of mortality worldwide, being responsible for millions of deaths annually. Therefore, novel cancer chemotherapeutic agents are urgently needed to combat this devastating disease. beta-Carboline alkaloids are an important class of natural products and medicinal molecules, which exert their anticancer activities through diverse mechanisms. In this review, we cover recent natural and synthetic beta-carbolines with anticancer activity that have been reported in the literature (2010-July 2014), focusing on their chemical structures, anticancer properties, structure-activity relationships, and mechanisms of action.

引用

页码：537 / 547

页数：11

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