Unique analytical considerations for laboratory studies identifying metabolic products of per- and polyfluoroalkyl substances (PFASs)

被引：25
作者：
Joudan, Shira [1 ]
Liu, Runzeng [1 ]
D'eon, Jessica C. [1 ]
Mabury, Scott A. [1 ]
机构：
[1] Univ Toronto, Dept Chem, 80 St George St, Toronto, ON M5S 3H6, Canada
来源：
TRAC-TRENDS IN ANALYTICAL CHEMISTRY | 2020年 / 124卷
基金：
加拿大自然科学与工程研究理事会;
关键词：
Per- and polyfluoroalkyl substances; Emerging contaminant; Biotransformation; Metabolism; Mass balance; Mass spectrometry; Non-target analysis; F-19; NMR; ISOMER-SPECIFIC BIOTRANSFORMATION; CHAIN PERFLUORINATED ACIDS; 82 FLUOROTELOMER ACRYLATE; RAT-LIVER MICROSOMES; IN-VITRO METABOLISM; AEROBIC BIOTRANSFORMATION; PHOSPHATE DIESTER; PERFLUOROALKYL SUBSTANCES; PERFLUOROOCTANE SULFONATE; MASS-SPECTROMETRY;
D O I：
10.1016/j.trac.2019.02.032
中图分类号：
O65 [分析化学];
学科分类号：
070302 ; 081704 ;
摘要：
Laboratory experiments investigating the biotransformation of per- and polyfluoroalkyl substances (PFASs) require unique analytical considerations due to the physicochemical properties of highly fluorinated molecules. Here, we review experiments performed using microbial systems, in vivo animal models or in vitro systems that search for novel transformation products. Researchers have made analytical decisions regarding volatility, polarity, purity and isomeric profiles of test compounds in the design of experiments, sampling procedures and analytical measurements. Identification of transformation products has been predominantly performed using ultra high-performance liquid chromatography- or gas chromatography-mass spectrometry, F-19 nuclear magnetic resonance and ion chromatography. In this review we will discuss attempts to close the mass balance in these experiments, and how future experiments can improve the comprehensive understanding of PFAS biotransformation. (C) 2019 Elsevier B.V. All rights reserved.
引用
收藏
页数：12
相关论文
共 90 条
  • [1] Comparative Assessment of the Global Fate and Transport Pathways of Long-Chain Perfluorocarboxylic Acids (PFCAs) and Perfluorocarboxylates (PFCs) Emitted from Direct Sources
    Armitage, James M.
    MacLeod, Matthew
    Cousins, Ian T.
    [J]. ENVIRONMENTAL SCIENCE & TECHNOLOGY, 2009, 43 (15) : 5830 - 5836
  • [2] Production of PFOS from aerobic soil biotransformation of two perfluoroalkyl sulfonamide derivatives
    Avendano, Sandra Mejia
    Liu, Jinxia
    [J]. CHEMOSPHERE, 2015, 119 : 1084 - 1090
  • [3] Biodegradation of N-Ethyl Perfluorooctane Sulfonamido Ethanol (EtFOSE) and EtFOSE-Based Phosphate Diester (SAmPAP Diester) in Marine Sediments
    Benskin, Jonathan P.
    Ikonomou, Michael G.
    Gobas, Frank A. P. C.
    Begley, Timothy H.
    Woudneh, Million B.
    Cosgrove, John R.
    [J]. ENVIRONMENTAL SCIENCE & TECHNOLOGY, 2013, 47 (03) : 1381 - 1389
  • [4] Perfluorinated Acid Isomer Profiling in Water and Quantitative Assessment of Manufacturing Source
    Benskin, Jonathan P.
    Yeung, Leo W. Y.
    Yamashita, Nobuyoshi
    Taniyasu, Sachi
    Lam, Paul K. S.
    Martin, Jonathan W.
    [J]. ENVIRONMENTAL SCIENCE & TECHNOLOGY, 2010, 44 (23) : 9049 - 9054
  • [5] Isomer-Specific Biotransformation Rates of a Perfluorooctane Sulfonate (PFOS)-Precursor by Cytochrome P450 Isozymes and Human Liver Microsomes
    Benskin, Jonathan P.
    Holt, Andrew
    Martin, Jonathan W.
    [J]. ENVIRONMENTAL SCIENCE & TECHNOLOGY, 2009, 43 (22) : 8566 - 8572
  • [6] Buck Robert C., 2011, Integrated Environmental Assessment and Management, V7, P513, DOI 10.1002/ieam.258
  • [7] BIOTRANSFORMATION PATHWAYS OF FLUOROTELOMER-BASED POLYFLUOROALKYL SUBSTANCES: A REVIEW
    Butt, Craig M.
    Muir, Derek C. G.
    Mabury, Scott A.
    [J]. ENVIRONMENTAL TOXICOLOGY AND CHEMISTRY, 2014, 33 (02) : 243 - 267
  • [8] BIOTRANSFORMATION OF THE 82 FLUOROTELOMER ACRYLATE IN RAINBOW TROUT 1 IN VIVO DIETARY EXPOSURE
    Butt, Craig M.
    Muir, Derek C. G.
    Mabury, Scott A.
    [J]. ENVIRONMENTAL TOXICOLOGY AND CHEMISTRY, 2010, 29 (12) : 2726 - 2735
  • [9] BIOTRANSFORMATION OF THE 82 FLUOROTELOMER ACRYLATE IN RAINBOW TROUT 2 IN VITRO INCUBATIONS WITH LIVER AND STOMACH S9 FRACTIONS
    Butt, Craig M.
    Muir, Derek C. G.
    Mabury, Scott A.
    [J]. ENVIRONMENTAL TOXICOLOGY AND CHEMISTRY, 2010, 29 (12) : 2736 - 2741
  • [10] Elucidating the Pathways of Poly- and Perfluorinated Acid Formation in Rainbow Trout
    Butt, Craig M.
    Muir, Derek C. G.
    Mabury, Scott A.
    [J]. ENVIRONMENTAL SCIENCE & TECHNOLOGY, 2010, 44 (13) : 4973 - 4980
123456789