Solution and microwave assisted synthesis of β-Cyclodextrin grafted polyacrylamide: Water treatment and In-vitro drug release study

The present article reports the application of beta-cyclodextrin grafted polyacrylamides synthesized through solution and microwave assisted polymerization techniques as flocculants and then the employment of partially hydrolyzed products of best grade of each technique in-vitro drug release study of diclofenac sodium. Five different grades of S-cyclodextrin grafted polyacrylamides by each of solution and microwave assisted polymerization techniques have been synthesized, by varying the monomer concentration. The synthesized polymers have been well characterized and their flocculation performances have been evaluated in kaolin suspension through settling and jar test methods Then the best performing grades of both the techniques have been partially hydrolyzed to prepare three different grades each technique by varying the concentration aqueous NaOH solution. Flocculation efficiencies of these polymers have been investigated in kaolin suspension. Thus best grades of partially hydrolyzed grafted polymers of each technique have been chosen for further study of drug delivery. In-vitro drug release study has been done using diclofenac sodium loaded microbeads prepared by ionic gelation method with two partially hydrolyzed grafted polymers (one from each technique) in phosphate buffer solution (PBS) at 37 +/- 0.5 degrees C and pH 7.4. The drug load and release have been analyzed by UV-vis spectroscopy. (C) 2017 Elsevier B.V. All rights reserved.