Effects of fluoroquinolone antibiotics on hepatic superoxide dismutase and glutathione peroxidase activities in healthy and experimentally induced peritonitis mice

In this study, effects of fluoroquinolone antibiotics were investigated on hepatic superoxide dismutase and glutathione peroxidase activities in healthy and experimentally induced peritonitis mice. One hundred thirty two mice randomly divided into six groups. Group 1 served as control, group 2 was injected enrofloxacin, group 3 was injected danofloxacin, group 4 was injected E. coli, and group 5 and group 6 were injected enrofloxacin and danofloxacin, respectively, after the injection E. roll. Hepatic superoxide dismutase and glutathione peroxidase activities were measured by spectrophotometer. As results, enrofloxacin caused a decrease glutathione peroxidase activity at 24, 48 and 72 hours, and danofloxacin caused an increase superoxide dismutase activity at 24 and 48 hours after the injection. Danofloxacin and E. coli caused a decrease glutathione peroxidase activity during all experimental period after the injection.