Flavonoid and Galloyl Glycosides Isolated from Saxifraga spinulosa and Their Antioxidative and Inhibitory Activities against Species That Cause Piroplasmosis

被引：31

作者：

Badral, Duger ^{[1
,2
]}

Odonbayar, Batsukh ^{[3
]}

Murata, Toshihiro ^{[3
]}

Munkhjargal, Tserendorj ^{[4
]}

Tuvshintulga, Bumduuren ^{[4
]}

Igarashi, Ikuo ^{[4
]}

Suganuma, Keisuke ^{[4
,5
]}

Inoue, Noboru ^{[6
]}

Brantner, Adelheid H. ^{[7
]}

Odontuya, Gendaram ^{[8
]}

Sasaki, Kenroh ^{[3
]}

Batkhuu, Javzan ^{[1
]}

机构：

[1] Natl Univ Mongolia, Sch Engn & Appl Sci, Ulaanbaatar 14201, Mongolia

[2] Mongolian Univ Pharmaceut Sci, Ulaanbaatar 18130, Mongolia

[3] Tohoku Med & Pharmaceut Univ, Dept Pharmacognosy, Aoba Ku, Sendai, Miyagi 9818558, Japan

[4] Obihiro Univ Agr & Vet Med, Natl Res Ctr Protozoan Dis, Obihiro, Hokkaido 0808555, Japan

[5] Obihiro Univ Agr & Vet Med, Res Ctr Global Agromed, Obihiro, Hokkaido 0808555, Japan

[6] Obihiro Univ Agr & Vet Med, Obihiro, Hokkaido 0808555, Japan

[7] Karl Franzens Univ Graz, Inst Pharmaceut Sci, Dept Pharmacognosy, A-8010 Graz, Austria

[8] Mongolian Acad Sci, Inst Chem & Chem Technol, Nat Prod Chem Lab, Ulaanbaatar 13330, Mongolia

来源：

JOURNAL OF NATURAL PRODUCTS | 2017年 / 80卷 / 09期

关键词：

ABSOLUTE-CONFIGURATION; CIRCULAR-DICHROISM; CONSTITUENTS; IDENTIFICATION; EXTRACTS; ASSIGNMENTS; GLUCOSIDES; AGLYCONE; TANNINS; BABESIA;

D O I：

10.1021/acs.jnatprod.7b00142

中图分类号：

Q94 [植物学];

学科分类号：

071001 ;

摘要：

Eight new flavonoid-based 3'-O-beta-D-glucopyranosides (1-8) and three new galloyl glucosides (9, 11, 12), were isolated from the aerial parts of Saxifraga spinulosa, along with 25 known compounds. The structures of the new compounds were elucidated by spectroscopic methods. Most of the isolated compounds exhibited potent DPPH radical-scavenging activities. Further, their inhibitory activities were evaluated against Babesia bovis, Babesia bigemina, Babesia caballi, and Theileria equi, protozoan parasites that cause piroplasmosis in livestock. The results indicated that several of these compounds showed growth-inhibitory effects on such organisms that cause piroplasmosis.

引用

页码：2416 / 2423

页数：8

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