Water-Soluble Spinel Ferrites by a Modified Polyol Process as Contrast Agents in MRI

被引：0

作者：

Basina, Georgia ^{[1
,2
]}

Tzitzios, Vasilis ^{[1
]}

Niarchos, Dimitris ^{[1
]}

Li, Wanfeng ^{[2
]}

Khurshid, Hafsa ^{[2
,4
]}

Mao, Hui

Hadjipanayis, Costas ^{[3
]}

Hadjipanayis, George ^{[2
]}

机构：

[1] NCSR Demokritos, Inst Mat Sci, Athens 15310, Greece

[2] Univ Delaware, Dept Phys & Astron, Newark, DE 19716 USA

[3] Emory Univ, Sch Med, Dept Neurol Surg, Atlanta, GA 30322 USA

[4] Emory Univ, Dept Radiol, Atlanta, GA 30322 USA

来源：

8TH INTERNATIONAL CONFERENCE ON THE SCIENTIFIC AND CLINICAL APPLICATIONS OF MAGNETIC CARRIERS | 2010年 / 1311卷

关键词：

Magnetic nanoparticles; MRI; magnetite; manganese ferrite; polyol method; MAGNETIC NANOPARTICLES;

D O I：

暂无

中图分类号：

O59 [应用物理学];

学科分类号：

摘要：

Magnetic nanoparticles have recently been very attractive for biomedical applications. In this study, we have synthesized ferrite nanoparticles for application as contrast agents in MRI experiments. Fe3O4 and MnFe2O4 spinet ferrites with a mean size of 11-12 nm, were prepared by a modified polyol route in commercially available polyethylene glycol with molecular weight 600 (PEG-600). The reaction takes place in the presence of water soluble and non-toxic triblock copolymer known as Pluronic (R) F-127 (PEO100-PPO65-PEO100). The nanoparticles have saturation magnetization values of 52 and 68 emu/g for MnFe2O4 and Fe3O4, respectively. Both the Fe3O4 and MnFe2O4 nanoparticles make stable solutions in water known as ferrofluids. Preliminary data demonstrated the capability of these nanoparticles to induce imaging contrast in T-2 weighted MRI experiments, making these materials suitable for biomedical applications such as medical MRI.

引用

页码：441 / +

页数：2

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