Bioactive Natural Products against Systemic Arterial Hypertension: A Past 20-Year Systematic and Prospective Review

被引:2
作者
da Silva, Maisa Gomes [1 ]
Fortes Barbosa, Sara Lea [1 ,2 ]
Silva, Diego Santos [1 ]
Meneses Bezerra, Isadora Basilio [1 ]
Bezerra, Erika Alves [1 ,2 ]
Coelho, Angelica Gomes [1 ]
Pinheiro da Silva Morais, Ilmara Cecilia [1 ]
Rezende-Junior, Luis Mario [1 ]
do Carmo, Iolanda Souza [2 ]
Lima-Neto, Jose De Sousa [3 ]
Comerma-Steffensen, Simon Gabriel [4 ,5 ]
das Gracas Lopes Cito, Antonia Maria [2 ]
Rufino Arcanjo, Daniel Dias [1 ]
机构
[1] Univ Fed Piaui, Dept Biophys & Physiol, Teresina, Piaui, Brazil
[2] Univ Fed Piaui, Dept Chem, Teresina, Piaui, Brazil
[3] Univ Fed Piaui, Fac Pharm, Teresina, Piaui, Brazil
[4] Aarhus Univ, Dept Biomed, Pulm & Cardiovasc Pharmacol, Aarhus, Denmark
[5] Cent Univ Venezuela, Vet Fac, Dept Biomed Sci Anim Physiol, Maracay, Aragua, Venezuela
关键词
ANGIOTENSIN-CONVERTING ENZYME; BLOOD-PRESSURE; MEDICINAL-PLANTS; OXIDATIVE STRESS; LEAF EXTRACT; DOCA-SALT; INHIBITORY-ACTIVITIES; CHLOROGENIC ACID; AQUEOUS EXTRACT; NITRIC-OXIDE;
D O I
10.1155/2022/8499625
中图分类号
R [医药、卫生];
学科分类号
10 ;
摘要
Background. Systemic arterial hypertension is one of the most common cardiovascular risks, corresponding to 45% of deaths involving CVDs. The use of natural products, such as medicinal plants, belongs to a millennial part of human therapeutics history and has been employed as an alternative anti-hypertensive treatment. Objective. The present review aims to prospect some natural products already experimentally assayed against arterial hypertension through scientific virtual libraries and patent documents over the past 20 years. Search strategy. This is a systematic review of the adoption of the PRISMA protocol and a survey of the scientific literature that synthesizes the results from published articles between 2001 and 2020 concerning the use of medicinal plants in the management of hypertension, including which parts of the plant or organism are used, as well as the mechanisms of action underlying the anti-hypertensive effect. Furthermore, a technological prospection was also carried out in patent offices from different countries in order to check technologies based on natural products claimed for the treatment or prevention of hypertension. Inclusion criteria. Scientific articles where a natural product had been experimentally assayed for anti-hypertensive activity (part of plants, plant extracts, and products derived from other organisms) were included. Data extraction and analysis. The selected abstracts of the articles and patent documents were submitted to a rigorous reading process. Those articles and patents that were not related to anti-hypertensive effects and claimed potential applications were excluded from the search. Results. Eighty specimens of biological species that showed anti-hypertensive activity were recovered, with 01 representative from the kingdom Fungi and 02 from the kingdom Protista, with emphasis on the families Asteraceae and Lamiaceae, with 6 representatives each. Leaves and aerial parts were the most used parts of the plants for the extraction of anti-hypertensive products, with maceration being the most used extraction method. Regarding phytochemical analyses, the most described classes of biomolecules in the reviewed works were alkaloids, terpenes, coumarins, flavonoids, and peptides, with the reduction of oxidative stress and the release of NO among the mechanisms of action most involved in this process. Regarding the number of patent filings, China was the country that stood out as the main one, with 813 registrations. Conclusion. The anti-hypertensive activity of natural products is still little explored in Western countries. Besides, China and India have shown more results in this area than other countries, confirming the strong influence of traditional medicine in these countries.
引用
收藏
页数:21
相关论文
共 128 条
  • [1] Blood pressure lowering effect of Ficus deltoidea var kunstleri in spontaneously hypertensive rats: possible involvement of renin-angiotensin-aldosterone system, endothelial function and anti-oxidant system
    Ab Azis, Norasikin
    Agarwal, Renu
    Ismail, Nafeeza Mohd
    Ismail, Nor Hadiani
    Kamal, Mohd Saleh Ahmad
    Radjeni, Zurain
    Singh, Harbindar Jeet
    [J]. MOLECULAR BIOLOGY REPORTS, 2019, 46 (03) : 2841 - 2849
  • [2] Effects of methanol extracts from roots, leaves, and fruits of the Lebanese strawberry tree (Arbutus andrachne) on cardiac function together with their antioxidant activity
    Abidi, Emna
    Habib, Jean
    Yassine, Ahmad
    Chahine, Nathalie
    Mahjoub, Touhami
    Elkak, Assem
    [J]. PHARMACEUTICAL BIOLOGY, 2016, 54 (06) : 1035 - 1041
  • [3] Anti-hypertensive effect of Moringa oleifera Lam
    Acuram, Lovely Kris
    Hernandez, Christine L. Chichioco
    [J]. COGENT BIOLOGY, 2019, 5 (01):
  • [4] Moringa oleifera leaf extract lowers high blood pressure by alleviating vascular dysfunction and decreasing oxidative stress in L-NAME hypertensive rats
    Aekthammarat, Direk
    Pannangpetch, Patchareewan
    Tangsucharit, Panot
    [J]. PHYTOMEDICINE, 2019, 54 : 9 - 16
  • [5] A new angiotensin - converting enzyme inhibitor from Peperomia pellucida (L.) Kunth
    Ahmad, Islamudin
    Ambarwati, Neneng Siti Silfi
    Elya, Berna
    Omar, Hanita
    Mulia, Kamarza
    Yanuar, Arry
    Negishi, Osamu
    Mun'im, Abdul
    [J]. ASIAN PACIFIC JOURNAL OF TROPICAL BIOMEDICINE, 2019, 9 (06) : 257 - 262
  • [6] Endothelium-independent and calcium channel-dependent relaxation of the porcine cerebral artery by different species and strains of turmeric
    Akter, Jesmin
    Islam, Md Zahorul
    Hossain, Md Amzad
    Kawabata, Shinsuke
    Takara, Kensaku
    Ha Thi Thanh Nguyen
    Hou, De-Xing
    Miyamoto, Atsushi
    [J]. JOURNAL OF TRADITIONAL AND COMPLEMENTARY MEDICINE, 2019, 9 (04): : 297 - 303
  • [7] Localization and function of angiotensin AT1 receptors
    Allen, AM
    Zhuo, JL
    Mendelsohn, FAO
    [J]. AMERICAN JOURNAL OF HYPERTENSION, 2000, 13 (01) : 31S - 38S
  • [8] Aqueous extract of dioscorea opposita thunb. normalizes the hypertension in 2K1C hypertensive rats
    Amat, Nurmuhammat
    Amat, Raziya
    Abdureyim, Sajida
    Hoxur, Parida
    Osman, Zulpiya
    Mamut, Dolkun
    Kijjoa, Anake
    [J]. BMC COMPLEMENTARY AND ALTERNATIVE MEDICINE, 2014, 14
  • [9] Araújo Messias Antônio de, 2004, Arq. Bras. Cardiol., V83, P404
  • [10] Aremu Olukayode O., 2019, Transactions of the Royal Society of South Africa, V74, P132, DOI 10.1080/0035919X.2019.1592031