Tendon and ligament mechanical loading in the pathogenesis of inflammatory arthritis

被引:152
作者
Gracey, Eric [1 ,2 ]
Burssens, Arne [1 ,3 ]
Cambre, Isabelle [1 ,2 ]
Schett, Georg [4 ,5 ]
Lories, Rik [6 ]
McInnes, Iain B. [7 ]
Asahara, Hiroshi [8 ,9 ]
Elewaut, Dirk [1 ,2 ]
机构
[1] Ghent Univ VIB, Ctr Inflammat Res, Mol Immunol & Inflammat Unit, Ghent, Belgium
[2] Ghent Univ Hosp, Dept Rheumatol, Ghent, Belgium
[3] Univ Ghent, Univ Ziekenhuis Gent, Dept Orthopaed & Traumatol, Ghent, Belgium
[4] Friedrich Alexander Univ Erlangen Nuremberg, Erlangen, Germany
[5] Univ Klinikum Erlangen, Erlangen, Germany
[6] Katholieke Univ Leuven, Skeletal Biol & Engn Res Ctr, Leuven, Belgium
[7] Univ Glasgow, Inst Infect Immun & Inflammat, Glasgow, Lanark, Scotland
[8] Scripps Res Inst, Dept Mol Med, San Diego, CA USA
[9] Grad Sch Med & Dent Sci, Dept Syst BioMed, Tokyo, Japan
基金
美国国家卫生研究院;
关键词
TRANSCRIPTION FACTOR MOHAWK; ANTI-INTERLEUKIN-17A MONOCLONAL-ANTIBODY; SOCIETY CLASSIFICATION CRITERIA; PSORIATIC-ARTHRITIS; ACHILLES-TENDON; ANKYLOSING-SPONDYLITIS; DOUBLE-BLIND; TGF-BETA; RHEUMATOID-ARTHRITIS; BONE-FORMATION;
D O I
10.1038/s41584-019-0364-x
中图分类号
R5 [内科学];
学科分类号
1002 ; 100201 ;
摘要
Mechanical loading is an important factor in the development of tendon and ligament disorders. In this Review, the authors discuss the evidence for the known role of mechanical loading in tendinopathy and its potential role in inflammatory arthritis. Mechanical loading is an important factor in musculoskeletal health and disease. Tendons and ligaments require physiological levels of mechanical loading to develop and maintain their tissue architecture, a process that is achieved at the cellular level through mechanotransduction-mediated fine tuning of the extracellular matrix by tendon and ligament stromal cells. Pathological levels of force represent a biological (mechanical) stress that elicits an immune system-mediated tissue repair pathway in tendons and ligaments. The biomechanics and mechanobiology of tendons and ligaments form the basis for understanding how such tissues sense and respond to mechanical force, and the anatomical extent of several mechanical stress-related disorders in tendons and ligaments overlaps with that of chronic inflammatory arthritis in joints. The role of mechanical stress in 'overuse' injuries, such as tendinopathy, has long been known, but mechanical stress is now also emerging as a possible trigger for some forms of chronic inflammatory arthritis, including spondyloarthritis and rheumatoid arthritis. Thus, seemingly diverse diseases of the musculoskeletal system might have similar mechanisms of immunopathogenesis owing to conserved responses to mechanical stress.
引用
收藏
页码:193 / 207
页数:15
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