More than the genes, the tumor microenvironment in neuroblastoma

被引：61
作者：
Borriello, Lucia [1 ,2 ,3 ]
Seeger, Robert C. [1 ,2 ,3 ]
Asgharzadeh, Shahab [1 ,2 ,3 ]
DeClerck, Yves A. [1 ,2 ,3 ,4 ]
机构：
[1] Childrens Hosp Los Angeles, Div Hematol Oncol & Blood & Marrow Transplantat, Los Angeles, CA 90027 USA
[2] Univ Southern Calif, Keck Sch Med, Dept Pediat, Los Angeles, CA 90089 USA
[3] Childrens Hosp Los Angeles, Saban Res Inst, Los Angeles, CA 90027 USA
[4] Univ Southern Calif, Keck Sch Med, Dept Biochem & Mol Biol, Los Angeles, CA 90089 USA
来源：
CANCER LETTERS | 2016年 / 380卷 / 01期
基金：
美国国家卫生研究院;
关键词：
Neuroblastoma; Tumor microenvironment; Hallmarks of cancer; Cell-cell communication; GROWTH-FACTOR RECEPTORS; NATURAL-KILLER-CELLS; N-MYC ONCOGENE; HIGH-RISK NEUROBLASTOMA; MESENCHYMAL STEM-CELLS; NEURO-BLASTOMA CELLS; FACTOR-I; TGF-BETA; EXTRACELLULAR-MATRIX; PERICYTE RECRUITMENT;
D O I：
10.1016/j.canlet.2015.11.017
中图分类号：
R73 [肿瘤学];
学科分类号：
100214 ;
摘要：
Neuroblastoma is the second most common solid tumor in children. Since the seminal discovery of the role of amplification of the MYCN oncogene in the pathogenesis of neuroblastoma in the 1980s, much focus has been on the contribution of genetic alterations in the progression of this cancer. However it is now clear that not only genetic events play a role but that the tumor microenvironment (TME) substantially contributes to the biology of neuroblastoma. In this article, we present a comprehensive review of the literature on the contribution of the TME to the ten hallmarks of cancer in neuroblastoma and discuss the mechanisms of communication between neuroblastoma cells and the TME that underlie the influence of the TME on neuroblastoma progression. We end our review by discussing how the knowledge acquired over the last two decades in this field is now leading to new clinical trials targeting the TME. (C) 2015 Elsevier Ireland Ltd. All rights reserved.
引用
收藏
页码：304 / 314
页数：11
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