Aptamer-functionalized DNA microgels: a strategy towards selective anticancer therapeutic systems

被引：23
作者：
Wang, Yitong [1 ,2 ]
Yan, Miaomiao [3 ]
Xu, Lu [1 ,2 ]
Zhao, Wenrong [1 ,2 ]
Wang, Xiaolin [1 ,2 ]
Dong, Shuli [1 ,2 ]
Hao, Jingcheng [1 ,2 ]
机构：
[1] Shandong Univ, Key Lab Colloid & Interface Chem, Minist Educ, Jinan 250100, Peoples R China
[2] Shandong Univ, Key Lab Special Aggregated Mat, Minist Educ, Jinan 250100, Peoples R China
[3] Binzhou Med Coll, Dept Pharm, Yantai 264003, Peoples R China
来源：
JOURNAL OF MATERIALS CHEMISTRY B | 2016年 / 4卷 / 32期
基金：
中国国家自然科学基金;
关键词：
THERMOSENSITIVE IONIC MICROGELS; DRUG-DELIVERY; INSULIN DELIVERY; NANOPARTICLES; RELEASE; CHEMOTHERAPY; PARTICLES; HYDROGELS; PLATFORM; GLUCOSE;
D O I：
10.1039/c6tb01224h
中图分类号：
TB3 [工程材料学]; R318.08 [生物材料学];
学科分类号：
0805 ; 080501 ; 080502 ;
摘要：
DNA microgels of oligonucleotides and polymers were constructed via a combination of DNA complementarity and photo-initiated free radical polymerization. The DNA microgels did not feature the conventional core-shell structure but were instead based on the copolymers of N-isopropylacrylamide and acrylamide and DNA crosslinks. By incorporating the aptamer-functionalized moieties, the AptMG-Dox system was demonstrated to possess excellent biocompatibility and highly selective killing efficacy for target cancer cells via stimuli-responsiveness, which could provide immense potential as an intelligent drug delivery carrier for targeted cancer therapy.
引用
收藏
页码：5446 / 5454
页数：9
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