Star-shaped fluorescent polypeptides

被引：64

作者：

Klok, HA ^{[1
]}

Hernández, JR ^{[1
]}

Becker, S ^{[1
]}

Müllen, K ^{[1
]}

机构：

[1] Max Planck Inst Polymer Res, D-55128 Mainz, Germany

来源：

JOURNAL OF POLYMER SCIENCE PART A-POLYMER CHEMISTRY | 2001年 / 39卷 / 10期

关键词：

polypeptides; ring-opening polymerization; alpha-amino acid N-carboxyanhydrides; star polymers; helix-coil transition;

D O I：

10.1002/pola.1133

中图分类号：

O63 [高分子化学（高聚物）];

学科分类号：

070305 ; 080501 ; 081704 ;

摘要：

Two series of novel, four-arm, star-shaped polypeptides were prepared via the ring-opening polymerization of gamma -benzyl-L-glutamate N-carboxyanhydride and epsilon -benzyloxycarbonyl-L-lysine N-carboxyanhydride with a tetra-amino-substituted perylene fluorophore as the initiator. The removal of the alpha -amino acid side-chain-protecting groups resulted in unprecedented water-soluble, perylene-functionalized, star-shaped polypeptides that showed strong fluorescence in aqueous solution. One of the features that distinguished these water-soluble star polypeptides from most other star polymers was that the conformation of the arms could be reversibly changed from a random coil into an a helix by variations in the pH of the aqueous solution. These star polypeptides might be of interest for the development of novel fluorescent probes or as traceable, stimuli-sensitive molecular containers. (C) 2001 John Wiley & Sons, Inc.

引用

页码：1572 / 1583

页数：12

共 34 条

[1]

[Anonymous], 1979, ADV POLYM SCI

[2] Globular carbohydrate macromolecule ''sugar balls'' .3. ''Radial-growth polymerization'' of sugar-substituted alpha-amino acid N-carboxyanhydrides (GlycoNCAs) with a dendritic initiator [J].