Zebrafish as a Model System to Study the Mechanism of Cutaneous Wound Healing and Drug Discovery: Advantages and Challenges

被引：32

作者：

Naomi, Ruth ^{[1
]}

Bahari, Hasnah ^{[1
]}

Yazid, Muhammad Dain ^{[2
]}

Embong, Hashim ^{[3
]}

Othman, Fezah ^{[4
]}

机构：

[1] Univ Putra Malaysia, Fac Med & Hlth Sci, Dept Human Anat, Serdang 43400, Malaysia

[2] Univ Kebangsaan Malaysia, Fac Med, Ctr Tissue Engn & Regenerat Med, Kuala Lumpur 56000, Malaysia

[3] Univ Kebangsaan Malaysia, Fac Med, Dept Emergency Med, Kuala Lumpur 56000, Malaysia

[4] Univ Putra Malaysia, Fac Med & Hlth Sci, Dept Biomed Sci, Serdang 43400, Malaysia

来源：

PHARMACEUTICALS | 2021年 / 14卷 / 10期

关键词：

zebrafish; wound healing; in vivo; signaling mechanism; advantages; challenges; drug discovery; SILVER NANOPARTICLES; DANIO-RERIO; DISEASE; SKIN; ANGIOGENESIS; REGENERATION; ACTIVATION; EMPHASIS; PROMOTES; ORGANISM;

D O I：

10.3390/ph14101058

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

In humans, cutaneous wounds may heal without scars during embryogenesis. However, in the adult phase, the similar wound may undergo a few events such as homeostasis, blood clotting, inflammation, vascularization, and the formation of granulation tissue, which may leave a scar at the injury site. In consideration of this, research evolves daily to improve the healing mechanism in which the wound may heal without scarring. In regard to this, zebrafish (Danio rerio) serves as an ideal model to study the underlying signaling mechanism of wound healing. This is an important factor in determining a relevant drug formulation for wound healing. This review scrutinizes the biology of zebrafish and how this favors the cutaneous wound healing relevant to the in vivo evidence. This review aimed to provide the current insights on drug discovery for cutaneous wound healing based on the zebrafish model. The advantages and challenges in utilizing the zebrafish model for cutaneous wound healing are discussed in this review. This review is expected to provide an idea to formulate an appropriate drug for cutaneous wound healing relevant to the underlying signaling mechanism. Therefore, this narrative review recapitulates current evidence from in vivo studies on the cutaneous wound healing mechanism, which favours the discovery of new drugs. This article concludes with the need for zebrafish as an investigation model for biomedical research in the future to ensure that drug repositions are well suited for human skin.

引用

页数：19