Facilitated Diffusion of Proteins on Chromatin

被引：59

作者：

Benichou, O. ^{[1
]}

Chevalier, C. ^{[1
]}

Meyer, B. ^{[1
]}

Voituriez, R. ^{[1
]}

机构：

[1] UPMC, CNRS, Lab Phys Theor Mat Condensee, F-75255 Paris, France

来源：

PHYSICAL REVIEW LETTERS | 2011年 / 106卷 / 03期

关键词：

DNA; KINETICS; LOCALIZATION; DYNAMICS;

D O I：

10.1103/PhysRevLett.106.038102

中图分类号：

O4 [物理学];

学科分类号：

0702 ;

摘要：

We present a theoretical model of facilitated diffusion of proteins in the cell nucleus. This model, which takes into account the successive binding and unbinding events of proteins to DNA, relies on a fractal description of the chromatin which has been recently evidenced experimentally. Facilitated diffusion is shown quantitatively to be favorable for a fast localization of a target locus by a transcription factor and even to enable the minimization of the search time by tuning the affinity of the transcription factor with DNA. This study shows the robustness of the facilitated diffusion mechanism, invoked so far only for linear conformations of DNA.

引用

页数：4

共 34 条

[1] Random walks on deterministic scale-free networks: Exact results
Agliari, E.
Burioni, R.
[J]. PHYSICAL REVIEW E, 2009, 80 (03):
[2] Exact mean first-passage time on the T-graph
Agliari, E.
[J]. PHYSICAL REVIEW E, 2008, 77 (01):
[3] Molecular crowding affects diffusion and binding of nuclear proteins in heterochromatin and reveals the fractal organization of chromatin
Bancaud, Aurelien
Huet, Sebastien
Daigle, Nathalie
Mozziconacci, Julien
Beaudouin, Joel
Ellenberg, Jan
[J]. EMBO JOURNAL, 2009, 28 (24) : 3785 - 3798
[4] Ben-Avraham D., 2000, Diffusion and reactions in fractals and disordered systems
[5] Bénichou O, 2010, NAT CHEM, V2, P472, DOI [10.1038/NCHEM.622, 10.1038/nchem.622]
[6] Searching Fast for a Target on DNA without Falling to Traps
Benichou, O.
Kafri, Y.
Sheinman, M.
Voituriez, R.
[J]. PHYSICAL REVIEW LETTERS, 2009, 103 (13)
[7] Zero constant formula for first-passage observables in bounded domains
Benichou, O.
Meyer, B.
Tejedor, V.
Voituriez, R.
[J]. PHYSICAL REVIEW LETTERS, 2008, 101 (13)
[8] Narrow-escape time problem:: Time needed for a particle to exit a confining domain through a small window
Benichou, O.
Voituriez, R.
[J]. PHYSICAL REVIEW LETTERS, 2008, 100 (16)
[9] Optimizing intermittent reaction paths
Benichou, O.
Loverdo, C.
Moreau, M.
Voituriez, R.
[J]. PHYSICAL CHEMISTRY CHEMICAL PHYSICS, 2008, 10 (47) : 7059 - 7072
[10] DIFFUSION-DRIVEN MECHANISMS OF PROTEIN TRANSLOCATION ON NUCLEIC-ACIDS .1. MODELS AND THEORY
BERG, OG
WINTER, RB
VONHIPPEL, PH
[J]. BIOCHEMISTRY, 1981, 20 (24) : 6929 - 6948

← 1 2 3 4 →