Vaccine Adjuvants: Putting Innate Immunity to Work

被引：1440

作者：

Coffman, Robert L. ^{[1
]}

Sher, Alan ^{[2
]}

Seder, Robert A. ^{[3
]}

机构：

[1] Dynavax Technol Corp, Berkeley, CA 94710 USA

[2] NIAID, Parasit Dis Lab, Bethesda, MD 20892 USA

[3] NIAID, Cellular Immunol Sect, Vaccine Res Ctr, Bethesda, MD 20892 USA

来源：

IMMUNITY | 2010年 / 33卷 / 04期

关键词：

PATTERN-RECOGNITION RECEPTORS; DENDRITIC CELL ACTIVATION; MONOPHOSPHORYL-LIPID-A; SINGLE-STRANDED RNA; HEPATITIS-B-VACCINE; TOLL-LIKE RECEPTORS; ADAPTIVE IMMUNITY; IMMUNOSTIMULATORY DNA; NALP3; INFLAMMASOME; ANTIBODY-RESPONSES;

D O I：

10.1016/j.immuni.2010.10.002

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

Adjuvants enhance immunity to vaccines and experimental antigens by a variety of mechanisms In the past decade, many receptors and signaling pathways in the innate immune system have been defined and these innate responses strongly influence the adaptive immune response The focus of this review is to delineate the innate mechanisms by which adjuvants mediate their effects We highlight how adjuvants can be used to influence the magnitude and alter the quality of the adaptive response in order to provide maximum protection against specific pathogens Despite the impressive success of currently approved adjuvants for generating immunity to viral and bacterial infections, there remains a need for improved adjuvants that enhance protective antibody responses, especially in populations that respond poorly to current vaccines However, the larger challenge is to develop vaccines that generate strong T cell immunity with purified or recombinant vaccine antigens

引用

页码：492 / 503

页数：12

共 112 条

[1] Recognition of double-stranded RNA and activation of NF-κB by Toll-like receptor 3 [J].