A review on the roles of electrical low-frequency deep brain stimulation and modulatory action of the serotonergic system in seizure

被引:0
作者
Gharib, Alireza [1 ]
Shojaie, Amir [2 ,3 ]
Zare, Meysam [2 ]
Komaki, Alireza [1 ]
Sarihi, Abdolrahman [1 ]
机构
[1] Hamadan Univ Med Sci, Neurophysiol Res Ctr, Hamadan, Iran
[2] Tarbiat Modares Univ, Fac Med Sci, Dept Physiol, Tehran, Iran
[3] ACECR, Royan Inst Stem Cell Biol & Technol, Cell Sci Res Ctr, Dept Brain & Cognit Sci, Tehran, Iran
来源
PHYSIOLOGY AND PHARMACOLOGY | 2019年 / 23卷 / 04期
关键词
Epilepsy; Low frequency stimulation; Neuromodulator; LONG-TERM POTENTIATION; CHRONIC CEREBELLAR STIMULATION; EPILEPTIFORM ACTIVITY; PERFORANT PATH; EXTRACELLULAR GLUTAMATE; KINDLING ACQUISITION; CORTICAL STIMULATION; GALANIN RECEPTORS; 5-HT2C RECEPTORS; SPATIAL MEMORY;
D O I
暂无
中图分类号
Q4 [生理学];
学科分类号
071003 ;
摘要
Epilepsy is a common neurological disorder that affects approximately 50 million people and about 30% of them have seizures despite antiepileptic-drug therapy. Even if 50% of these 600,000 or so patients benefit from surgical resection, many would still need new therapeutic approaches. Deep brain stimulation (DBS) has been suggested as an alternative to drug therapy. Low frequency stimulation (LFS) is an effective pattern of DBS that can decrease epileptic seizures. The incidence of epileptic seizures has been described by an imbalance between excitatory (glutamatergic) and inhibitory (GABAergic) neurotransmission. This phenomenon may be affected by other neurotransmitter systems, including serotonin (5-hydroxytryptamine, 5-HT). The Serotonergic system undergoes many alterations in the epileptic brain. The link between LFS and serotonin release has been studied and it is documented that 5-HT1A receptor antagonist reduces the anti-convulsant effects of LFS. Thus, considering the effects of the serotonergic system in neuronal activities in the epileptic brain, it may be involved in the anti-convulsant mechanism(s) of LFS. In this review, we introduce the effects of low frequency stimulation on seizure and its possible mechanisms. The role of some neuromodulators in mediating the anti-convulsive effects of LFS and the probable signaling changes will be discussed.
引用
收藏
页码:235 / 248
页数:14
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