Association between CRP and TNF-α genes Variants and Cardiovascular Heart Disease in a Mexican Population: Protocol for a Case-Control Study

被引：11

作者：

Hernandez-Diaz, Yazmin ^{[1
]}

Alfonso Tovilla-Zarate, Carlos ^{[2
]}

Juarez-Rojop, Isela ^{[3
]}

Lilia Lopez-Narvaez, Maria ^{[4
]}

Francisco Alvarez-Camara, Jose ^{[3
]}

Beatriz Gonzalez-Castro, Thelma ^{[1
]}

机构：

[1] Univ Juarez Autonoma Tabasco, Div Acad Multidisciplinaria Jalpa de Mendez, Jalpa De Mendez 86205, Tabasco, Mexico

[2] Univ Juarez Autonoma Tabasco, Div Multidisciplinaria Comalcalco, Comalcalco 86650, Tabasco, Mexico

[3] Univ Juarez Autonoma Tabasco Villahermosa, Div Acad Ciencias Salud, Tabasco 86150, Mexico

[4] Hosp Gen Yajalon, Secretaria Salud, Yajalon 29932, Chiapas, Mexico

来源：

INTERNATIONAL JOURNAL OF ENVIRONMENTAL RESEARCH AND PUBLIC HEALTH | 2016年 / 13卷 / 01期

关键词：

CAD; CRP; TNF-alpha; association studies; Mexican population; C-REACTIVE PROTEIN; CORONARY-ARTERY-DISEASE; NECROSIS-FACTOR-ALPHA; MYOCARDIAL-INFARCTION; METABOLIC SYNDROME; POLYMORPHISMS; RISK; INFLAMMATION; MARKERS; ATHEROSCLEROSIS;

D O I：

10.3390/ijerph13010103

中图分类号：

X [环境科学、安全科学];

学科分类号：

08 ; 0830 ;

摘要：

Background: The C-reactive protein (CRP) and the tumor necrosis factor-alpha (TNF-alpha) are considered markers of inflammation and have been shown to predict the risk of incident cardiovascular events. However, few studies have undertaken a comprehensive examination of SNPs (single nucleotide polymorphisms) of the CRP and TNF-alpha genes; due to this, we will present a protocol study to evaluate the role of the CRP and TNF-alpha genes in Mexican individuals. Methods/design: we will perform a case-control study to explore the CRP and TNF-alpha genotype distribution as well as the serum influence of rs1800947, rs1130864, rs2794521 and rs1205 (polymorphisms of the CRP gene) and rs361525, rs1800629, rs1799724, rs1800630, rs1799964 (of the TNF-alpha gene) in Mexican individuals who present coronary artery disease. Ethics and dissemination: a written informed consent will be obtained from all the participating subjects. An article detailing the results of the study will be submitted for publication in an international peer-reviewed journal, in accordance with STROBE criteria.

引用

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