Association between CRP and TNF-α genes Variants and Cardiovascular Heart Disease in a Mexican Population: Protocol for a Case-Control Study

Background: The C-reactive protein (CRP) and the tumor necrosis factor-alpha (TNF-alpha) are considered markers of inflammation and have been shown to predict the risk of incident cardiovascular events. However, few studies have undertaken a comprehensive examination of SNPs (single nucleotide polymorphisms) of the CRP and TNF-alpha genes; due to this, we will present a protocol study to evaluate the role of the CRP and TNF-alpha genes in Mexican individuals. Methods/design: we will perform a case-control study to explore the CRP and TNF-alpha genotype distribution as well as the serum influence of rs1800947, rs1130864, rs2794521 and rs1205 (polymorphisms of the CRP gene) and rs361525, rs1800629, rs1799724, rs1800630, rs1799964 (of the TNF-alpha gene) in Mexican individuals who present coronary artery disease. Ethics and dissemination: a written informed consent will be obtained from all the participating subjects. An article detailing the results of the study will be submitted for publication in an international peer-reviewed journal, in accordance with STROBE criteria.