Durability of Heterologous and Homologous COVID-19 Vaccine Boosts

被引：42

作者：

Tan, C. Sabrina ^{[1
]}

Collier, Ai-ris Y. ^{[1
]}

Yu, Jingyou ^{[1
]}

Liu, Jinyan ^{[1
]}

Chandrashekar, Abishek ^{[1
]}

McMahan, Katherine ^{[1
]}

Jacob-Dolan, Catherine ^{[1
]}

He, Xuan ^{[1
]}

Roy, Vicky ^{[2
]}

Hauser, Blake M. ^{[2
]}

Munt, Jennifer E. ^{[3
]}

Mallory, Michael L. ^{[3
]}

Mattocks, Melissa ^{[3
]}

Powers, John M. ^{[3
]}

Meganck, Rita M. ^{[3
]}

Rowe, Marjorie ^{[1
]}

Hemond, Rachel ^{[1
]}

Bondzie, Esther A. ^{[1
]}

Jaegle, Kate H. ^{[1
]}

Baric, Ralph S. ^{[3
]}

Schmidt, Aaron G. ^{[2
]}

Alter, Galit ^{[2
]}

Le Gars, Mathieu ^{[4
]}

Sadoff, Jerald ^{[4
]}

Barouch, Dan H. ^{[1
]}

机构：

[1] Beth Israel Deaconess Med Ctr, Ctr Virol & Vaccine Res, 330 Brookline Ave,E CLS 1043, Boston, MA 02115 USA

[2] Ragon Inst Massachusetts Gen Hosp Mit & Harvard, 77 Massachusetts Ave, Cambridge, MA 02139 USA

[3] Univ N Carolina, Chapel Hill, NC 27515 USA

[4] Janssen Vaccines & Prevent, Leiden, Netherlands

来源：

JAMA NETWORK OPEN | 2022年 / 5卷 / 08期

基金：

美国国家卫生研究院;

关键词：

SARS-COV-2; IMMUNITY;

D O I：

10.1001/jamanetworkopen.2022.26335

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

IMPORTANCE Antibody responses elicited by current messenger RNA (mRNA) COVID-19 vaccines decline rapidly and require repeated boosting OBJECTIVE To evaluate the immunogenicity and durability of heterologous and homologous prime-boost regimens involving the adenovirus vector vaccine Ad26.COV2.S and the mRNA vaccine BNT162b2. DESIGN, SETTING, AND PARTICIPANTS In this cohort study at a single clinical site in Boston, Massachusetts, 68 individuals who were vaccinated at least 6 months previously with 2 immunizations of BNT162b2 were boosted with either Ad26.COV2.S or BNT162b2. Enrollment of participants occurred from August 12, 2021, to October 25, 2021, and this study involved 4 months of follow-up. Data analysis was performed from November 2021 to February 2022. EXPOSURES Participants who were previously vaccinated with BNT162b2 received a boost with either Ad26.COV2.S or BNT162b2. MAIN OUTCOMES AND MEASURES Humoral immune responses were assessed by neutralizing, binding, and functional antibody responses for 16 weeks following the boost. CD8(+) and CD4(+) T-cell responses were evaluated by intracellular cytokine staining assays. RESULTS Among 68 participants who were originally vaccinated with BNT162b2 and boosted with Ad26.COV2.S (41 participants; median [range] age, 36 [23-84] years) or BNT162b2 (27 participants; median [range] age, 35 [23-76] years), 56 participants (82%) were female, 7 (10%) were Asian, 4 (6%) were Black, 4 (6%) were Hispanic or Latino, 3 (4%) were more than 1 race, and 53 (78%) were White. Both vaccines were found to be associated with increased humoral and cellular immune responses, including against SARS-CoV-2 variants of concern. BNT162b2 boosting was associated with a rapid increase of Omicron neutralizing antibodies that peaked at a median (IQR) titer of 1018 (699-1646) at week 2 and declined by 6.9-fold to a median (IQR) titer of 148 (95-266) by week 16. Ad26.COV2.S boosting was associated with increased Omicron neutralizing antibodies titers that peaked at a median (IQR) of 859 (467-1838) week 4 and declined by 2.1-fold to a median (IQR) of 403 (208-1130) by week 16. CONCLUSIONS AND RELEVANCE Heterologous Ad26.COV2.S boosting was associated with durable humoral and cellular immune responses in individuals who originally received the BNT162b2 vaccine. These data suggest potential benefits of heterologous prime-boost vaccine regimens for SARS-CoV-2.

引用

页数：11

共 38 条

[1] Immunogenicity of Ad26.COV2.S vaccine against SARS-CoV-2 variants in humans [J].

Alter, Galit ;

Yu, Jingyou ;

Liu, Jinyan ;

Chandrashekar, Abishek ;

Borducchi, Erica N. ;

Tostanoski, Lisa H. ;

McMahan, Katherine ;

Jacob-Dolan, Catherine ;

Martinez, David R. ;

Chang, Aiquan ;

Anioke, Tochi ;

Lifton, Michelle ;

Nkolola, Joseph ;

Stephenson, Kathryn E. ;

Atyeo, Caroline ;

Shin, Sally ;

Fields, Paul ;

Kaplan, Ian ;

Robins, Harlan ;

Amanat, Fatima ;

Krammer, Florian ;

Baric, Ralph S. ;

Le Gars, Mathieu ;

Sadoff, Jerald ;

de Groot, Anne Marit ;

Heerwegh, Dirk ;

Struyf, Frank ;

Douoguih, Macaya ;

van Hoof, Johan ;

Schuitemaker, Hanneke ;

Barouch, Dan H. .

NATURE, 2021, 596 (7871) :268-+

[2] Homologous and Heterologous Covid-19 Booster Vaccinations [J].

Atmar, R. L. ;

Lyke, K. E. ;

Deming, M. E. ;

Jackson, L. A. ;

Branche, A. R. ;

El Sahly, H. M. ;

Rostad, C. A. ;

Martin, J. M. ;

Johnston, C. ;

Rupp, R. E. ;

Mulligan, M. J. ;

Brady, R. C. ;

Frenck, R. W., Jr. ;

Backer, M. ;

Kottkamp, A. C. ;

Babu, T. M. ;

Rajakumar, K. ;

Edupuganti, S. ;

Dobrzynski, D. ;

Coler, R. N. ;

Posavad, C. M. ;

Archer, J., I ;

Crandon, S. ;

Nayak, S. U. ;

Szydlo, D. ;

Zemanek, J. A. ;

Islas, C. P. Dominguez ;

Brown, E. R. ;

Suthar, M. S. ;

McElrath, M. J. ;

McDermott, A. B. ;

Montefiori, D. C. ;

Eaton, A. ;

Neuzil, K. M. ;

Stephens, D. S. ;

Roberts, P. C. ;

Beigel, J. H. .

NEW ENGLAND JOURNAL OF MEDICINE, 2022, 386 (11) :1046-1057

[3] Efficacy and Safety of the mRNA-1273 SARS-CoV-2 Vaccine [J].

Baden, Lindsey R. ;

El Sahly, Hana M. ;

Essink, Brandon ;

Kotloff, Karen ;

Frey, Sharon ;

Novak, Rick ;

Diemert, David ;

Spector, Stephen A. ;

Rouphael, Nadine ;

Creech, C. Buddy ;

McGettigan, John ;

Khetan, Shishir ;

Segall, Nathan ;

Solis, Joel ;

Brosz, Adam ;

Fierro, Carlos ;

Schwartz, Howard ;

Neuzil, Kathleen ;

Corey, Larry ;

Gilbert, Peter ;

Janes, Holly ;

Follmann, Dean ;

Marovich, Mary ;

Mascola, John ;

Polakowski, Laura ;

Ledgerwood, Julie ;

Graham, Barney S. ;

Bennett, Hamilton ;

Pajon, Rolando ;

Knightly, Conor ;

Leav, Brett ;

Deng, Weiping ;

Zhou, Honghong ;

Han, Shu ;

Ivarsson, Melanie ;

Miller, Jacqueline ;

Zaks, Tal .

NEW ENGLAND JOURNAL OF MEDICINE, 2021, 384 (05) :403-416

[4] Protection by a Fourth Dose of BNT162b2 against Omicron in Israel [J].

Bar-On, Yinon M. ;

Goldberg, Yair ;

Mandel, Micha ;

Bodenheimer, Omri ;

Amir, Ofra ;

Freedman, Laurence ;

Alroy-Preis, Sharon ;

Ash, Nachman ;

Huppert, Amit ;

Milo, Ron .

NEW ENGLAND JOURNAL OF MEDICINE, 2022, 386 (18) :1712-1720

[5] Durable Humoral and Cellular Immune Responses 8 Months after Ad26.COV2.S Vaccination [J].

Barouch, Dan H. ;

Stephenson, Kathryn E. ;

Sadoff, Jerald ;

Yu, Jingyou ;

Chang, Aiquan ;

Gebre, Makda ;

McMahan, Katherine ;

Liu, Jinyan ;

Chandrashekar, Abishek ;

Patel, Shivani ;

Le Gars, Mathieu ;

de Groot, Anne M. ;

Heerwegh, Dirk ;

Struyf, Frank ;

Douoguih, Macaya ;

van Hoof, Johan ;

Schuitemaker, Hanneke .

NEW ENGLAND JOURNAL OF MEDICINE, 2021, 385 (10) :951-953

[6] Activity of convalescent and vaccine serum against SARS-CoV-2 Omicron [J].

Carreno, Juan Manuel ;

Alshammary, Hala ;

Tcheou, Johnstone ;

Singh, Gagandeep ;

Raskin, Ariel J. ;

Kawabata, Hisaaki ;

Sominsky, Levy A. ;

Clark, Jordan J. ;

Adelsberg, Daniel C. ;

Bielak, Dominika A. ;

Gonzalez-Reiche, Ana Silvia ;

Dambrauskas, Nicholas ;

Vigdorovich, Vladimir ;

Srivastava, Komal ;

Sather, D. Noah ;

Sordillo, Emilia Mia ;

Bajic, Goran ;

van Bakel, Harm ;

Simon, Viviana ;

Krammer, Florian .

NATURE, 2022, 602 (7898) :682-+

[7] Omicron extensively but incompletely escapes Pfizer BNT162b2 neutralization [J].

Cele, Sandile ;

Jackson, Laurelle ;

Khoury, David S. ;

Khan, Khadija ;

Moyo-Gwete, Thandeka ;

Tegally, Houriiyah ;

San, James Emmanuel ;

Cromer, Deborah ;

Scheepers, Cathrine ;

Amoako, Daniel G. ;

Karim, Farina ;

Bernstein, Mallory ;

Lustig, Gila ;

Archary, Derseree ;

Smith, Muneerah ;

Ganga, Yashica ;

Jule, Zesuliwe ;

Reedoy, Kajal ;

Hwa, Shi-Hsia ;

Giandhari, Jennifer ;

Blackburn, Jonathan M. ;

Gosnell, Bernadett, I ;

Karim, Salim S. Abdool ;

Hanekom, Willem ;

von Gottberg, Anne ;

Bhiman, Jinal N. ;

Lessells, Richard J. ;

Moosa, Mahomed-Yunus S. ;

Davenport, Miles P. ;

de Oliveira, Tulio ;

Moore, Penny L. ;

Sigal, Alex .

NATURE, 2022, 602 (7898) :654-+

[8] Dissecting Polyclonal Vaccine-Induced Humoral Immunity against HIV Using Systems Serology [J].

Chung, Amy W. ;

Kumar, Manu P. ;

Arnold, Kelly B. ;

Yu, Wen Han ;

Schoen, Matthew K. ;

Dunphy, Laura J. ;

Suscovich, Todd J. ;

Frahm, Nicole ;

Linde, Caitlyn ;

Mahan, Alison E. ;

Hoffner, Michelle ;

Streeck, Hendrik ;

Ackerman, Margaret E. ;

McElrath, M. Juliana ;

Schuitemaker, Hanneke ;

Pau, Maria G. ;

Baden, Lindsey R. ;

Kim, Jerome H. ;

Michael, Nelson L. ;

Barouch, Dan H. ;

Lauffenburger, Douglas A. ;

Alter, Galit .

CELL, 2015, 163 (04) :988-998

[9] Effectiveness of BNT162b2 Vaccine against Omicron Variant in South Africa [J].

Collie, Shirley ;

Champion, Jared ;

Moultrie, Harry ;

Bekker, Linda-Gail ;

Gray, Glenda .

NEW ENGLAND JOURNAL OF MEDICINE, 2022, 386 (05) :494-496

[10] Differential Kinetics of Immune Responses Elicited by Covid-19 Vaccines [J].

Collier, Ai-ris Y. ;

Yu, Jingyou ;

McMahan, Katherine ;

Liu, Jinyan ;

Chandrashekar, Abishek ;

Maron, Jenny S. ;

Atyeo, Caroline ;

Martinez, David R. ;

Ansel, Jessica L. ;

Aguayo, Ricardo ;

Rowe, Marjorie ;

Jacob-Dolan, Catherine ;

Sellers, Daniel ;

Barrett, Julia ;

Ahmad, Kunza ;

Anioke, Tochi ;

VanWyk, Haley ;

Gardner, Sarah ;

Powers, Olivia ;

Bondzie, Esther A. ;

Wan, Huahua ;

Baric, Ralph S. ;

Alter, Galit ;

Hacker, Michele R. ;

Barouch, Dan H. .

NEW ENGLAND JOURNAL OF MEDICINE, 2021, 385 (21) :2010-2012

← 1 2 3 4 →