Three new cases of non-Hodgkin lymphoma with t(9;14)(p13;q32)

被引：10
作者：
Andrieux, J
Fert-Ferrer, S
Copin, MC
Huyghe, P
Pocachard, P
Lespinasse, J
Bauters, F
Lai, JL
Quesnel, B
机构：
[1] Ctr Hosp Reg & Univ Lille, Hop Jeanne de Flandre, Med Genet Lab, F-59037 Lille, France
[2] INSERM, U524, F-59045 Lille, France
[3] CH, Lab Genet Chromosom, Chambery, France
[4] CHRU, Hop Calmette, Lab Anat & Cytol Pathol, Lille, France
[5] CHRU, Serv Malad Sang, Lille, France
[6] CH, Lab Anat & Cytol Pathol, Chambery, France
来源：
CANCER GENETICS AND CYTOGENETICS | 2003年 / 145卷 / 01期
关键词：
D O I：
10.1016/S0165-4608(03)00054-2
中图分类号：
R73 [肿瘤学];
学科分类号：
100214 ;
摘要：
The majority of non-Hodgkin lymphomas of B-cell type (B-NHL) exhibit chromosomal abnormalities including, many types of reciprocal translocations closely related to specific histopathologic entities. The t(9;14)(p13;q32) has been recognized as a primary genetic event directly involved in the development of lymphoplasmacytic lymphoma. In the 14 published cases, the t(9;14)(p13;32) seems to delineate a variety of low-grade B-cell disorders characterized by a common clinical history and immunopathologic similarities. We report here three new cases presenting a t(9;14)(p13;q32) with other chromosomal abnormalities which have been referred to as B-cell low-grade or high-grade malignant lymphoproliferative disorders. Two of these cases showed diffuse large B cell lymphoma morphology and two patients had a favorable clinical outcome. These data suggest that t(9;14)(p13-.q32) is not restricted to low-grade lymphoma. (C) 2003 Elsevier Inc. All rights reserved.
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收藏
页码：65 / 69
页数：5
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