Naphthalenones and isocoumarins from a Costa Rican fungus Xylariaceae sp CR1546C

被引：13

作者：

Kim, Ki Hyun ^{[1
]}

Beemelmanns, Christine ^{[2
]}

Murillo, Catalina ^{[3
]}

Guillen, Anny ^{[3
]}

Umana, Loengrin ^{[3
]}

Tamayo-Castillo, Giselle ^{[3
,4
,5
]}

Kim, Su-Nam ^{[6
]}

Clardy, Jon ^{[7
]}

Cao, Shugeng ^{[7
,8
]}

机构：

[1] Sungkyunkwan Univ, Sch Pharm, Nat Prod Res Lab, Suwon 440746, South Korea

[2] HKI, Leibniz Inst Nat Prod Res & Infect Biol eV, D-07745 Jena, Germany

[3] Inst Nacl Biodiversidad INBio, Unidad Estrateg Bioprospecc, Santo Domingo, Costa Rica

[4] Univ Costa Rica, Escuela Quim, San Jose, Costa Rica

[5] Univ Costa Rica, CIPRONA, San Jose, Costa Rica

[6] KIST Gangneung Inst, Nat Prod Res Ctr, Kangnung 210340, South Korea

[7] Harvard Univ, Sch Med, Dept Biol Chem & Mol Pharmacol, Boston, MA 02115 USA

[8] Univ Hawaii, Ctr Canc, Honolulu, HI 96813 USA

来源：

JOURNAL OF CHEMICAL RESEARCH | 2014年 / 12期

关键词：

Xylariaceae sp; naphthalenone; isocoumarin; antifungal activity; ENDOPHYTIC FUNGUS; BIOSYNTHESIS; METABOLITES; SUBSTANCES;

D O I：

10.3184/174751914X14175406270662

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

A new naphthalenone, (R)-4,6,8-trihydroxy-3,4-dihydro-1(2H)-naphthalenone and a new isocoumarin, 6,8-dihydroxy(3R)-(2-oxopropyl)-3,4-dihydroisocoumarin, together with eight related known compounds were isolated from the endolichenic fungal species, CR1546C from Costa Rican lichen Sticta fuliginosa (Lobariaceae). Their structures were elucidated by spectroscopic methods, including extensive 1D- and 2D-NMR techniques and chemical methods. All of the isolated compounds exhibited moderate antifungal activity against the yeast Candida albicans.

引用

页码：722 / 725

页数：4

共 22 条

[1] Inhibition of Tumor Cells Interacting with Stromal Cells by Xanthones Isolated from a Costa Rican Penicillium sp. [J].