Focal adhesions in osteoneogenesis

被引：88

作者：

Biggs, M. J. P. ^{[1
]}

Dalby, M. J. ^{[2
]}

机构：

[1] Columbia Univ, Dept Appl Phys & Appl Math, Nanotechnol Ctr Mech Regenerat Med, New York, NY 10027 USA

[2] Univ Glasgow, Inst Biomed & Life Sci, Ctr Cell Engn, Glasgow, Lanark, Scotland

来源：

PROCEEDINGS OF THE INSTITUTION OF MECHANICAL ENGINEERS PART H-JOURNAL OF ENGINEERING IN MEDICINE | 2010年 / 224卷 / H12期

基金：

英国生物技术与生命科学研究理事会;

关键词：

focal adhesions; biomaterials; differentiation; cell signalling; MESENCHYMAL STEM-CELLS; BONE MORPHOGENETIC PROTEIN-2; OSTEOBLAST-LIKE CELLS; GENE-EXPRESSION; OSTEOGENIC DIFFERENTIATION; NANOSCALE TOPOGRAPHY; SIGNAL-TRANSDUCTION; INTEGRIN; KINASE; SURFACE;

D O I：

10.1243/09544119JEIM775

中图分类号：

R318 [生物医学工程];

学科分类号：

0831 ;

摘要：

As materials technology and the field of tissue engineering advance, the role of cellular adhesive mechanisms, in particular, interactions with implantable devices, becomes more relevant in both research and clinical practice. A key tenet of medical device technology is to use the exquisite ability of biological systems to respond to the material surface or chemical stimuli in order to help to develop next-generation biomaterials. The focus of this review is on recent studies and developments concerning focal adhesion formation in osteoneogenesis, with an emphasis on the influence of synthetic constructs on integrin-mediated cellular adhesion and function.

引用

页码：1441 / 1453

页数：13

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